Hypma_009124 protein (Hypsizygus marmoreus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

Hypma_009124

Actin-related protein 8; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Belongs to the actin family. (683 aa)

Predicted Functional Partners:

ARP4

0.993

ies6

0.989

arp5

0.984

INO80

0.981

RVB1_0

0.979

RVB1_1

0.979

RVB2

0.970

ACT1

0.967

ACTZ

0.967

ITSN2

0.965

Your Current Organism:

Hypsizygus marmoreus

NCBI taxonomy Id: 39966
Other names: H. marmoreus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACT1	ARP4	A0A369J7D3	A0A369JPY8	Actin-1.	Actin-related protein 4; Belongs to the actin family.	0.974
ACT1	Hypma_009124	A0A369J7D3	A0A369JUF8	Actin-1.	Actin-related protein 8; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Belongs to the actin family.	0.967
ACT1	INO80	A0A369J7D3	A0A369K7K0	Actin-1.	Putative DNA helicase INO80.	0.906
ACT1	ITSN2	A0A369J7D3	A0A369JB64	Actin-1.	Intersectin-2.	0.966
ACT1	RVB1_0	A0A369J7D3	A0A369J902	Actin-1.	RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.	0.881
ACT1	RVB1_1	A0A369J7D3	A0A369JIM5	Actin-1.	RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.	0.881
ACT1	RVB2	A0A369J7D3	A0A369JGD6	Actin-1.	RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.	0.935
ACT1	arp5	A0A369J7D3	A0A369K831	Actin-1.	Actin-like protein arp5; Belongs to the actin family.	0.859
ACT1	ies6	A0A369J7D3	A0A369KAV6	Actin-1.	Chromatin-remodeling complex subunit ies6.	0.854
ACTZ	ARP4	A0A369KCT0	A0A369JPY8	Actin-2; Belongs to the actin family.	Actin-related protein 4; Belongs to the actin family.	0.975
ACTZ	Hypma_009124	A0A369KCT0	A0A369JUF8	Actin-2; Belongs to the actin family.	Actin-related protein 8; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Belongs to the actin family.	0.967
ACTZ	INO80	A0A369KCT0	A0A369K7K0	Actin-2; Belongs to the actin family.	Putative DNA helicase INO80.	0.906
ACTZ	ITSN2	A0A369KCT0	A0A369JB64	Actin-2; Belongs to the actin family.	Intersectin-2.	0.966
ACTZ	RVB1_0	A0A369KCT0	A0A369J902	Actin-2; Belongs to the actin family.	RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.	0.881
ACTZ	RVB1_1	A0A369KCT0	A0A369JIM5	Actin-2; Belongs to the actin family.	RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.	0.881
ACTZ	RVB2	A0A369KCT0	A0A369JGD6	Actin-2; Belongs to the actin family.	RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.	0.935
ACTZ	arp5	A0A369KCT0	A0A369K831	Actin-2; Belongs to the actin family.	Actin-like protein arp5; Belongs to the actin family.	0.859
ACTZ	ies6	A0A369KCT0	A0A369KAV6	Actin-2; Belongs to the actin family.	Chromatin-remodeling complex subunit ies6.	0.854
ARP4	ACT1	A0A369JPY8	A0A369J7D3	Actin-related protein 4; Belongs to the actin family.	Actin-1.	0.974
ARP4	ACTZ	A0A369JPY8	A0A369KCT0	Actin-related protein 4; Belongs to the actin family.	Actin-2; Belongs to the actin family.	0.975

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

16

average node degree:

2.91

avg. local clustering coefficient:

0.891

expected number of edges:

13

PPI enrichment p-value:

0.261

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006307

DNA dealkylation involved in DNA repair

5 of 8

2.58

4.22

8.03e-09

GO:0006285

Base-excision repair, AP site formation

3 of 5

2.56

2.52

1.97e-05

GO:0051409

Response to nitrosative stress

3 of 7

2.41

2.34

3.68e-05

GO:0006281

DNA repair

6 of 88

1.61

2.3

7.28e-07

GO:0090304

Nucleic acid metabolic process

10 of 418

1.16

1.59

8.03e-09

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0052822

DNA-3-methylguanine glycosylase activity

3 of 3

2.78

2.57

1.93e-05

GO:0052821

DNA-7-methyladenine glycosylase activity

3 of 3

2.78

2.57

1.93e-05

GO:0043916

DNA-7-methylguanine glycosylase activity

3 of 4

2.66

2.53

2.02e-05

GO:0032131

Alkylated DNA binding

3 of 4

2.66

2.53

2.02e-05

GO:0008725

DNA-3-methyladenine glycosylase activity

3 of 5

2.56

2.48

2.31e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032993

protein-DNA complex

3 of 24

1.88

1.42

0.0014

GO:0009274

Peptidoglycan-based cell wall

4 of 257

0.97

0.58

0.0230

GO:0005737

Cytoplasm

9 of 1809

0.48

0.33

0.0199

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:910

DNA dealkylation

5 of 6

2.7

4.52

2.83e-09

CL:757

DNA repair, and DNA replication

6 of 100

1.56

2.09

2.23e-06

CL:551

Mixed, incl. RNA polymerase, and Sigma-70 factor, region 1.2

3 of 11

2.22

1.84

0.00029

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03410

Base excision repair

6 of 30

2.08

4.02

1.07e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0489

Methyltransferase

5 of 120

1.4

1.39

0.00020

KW-0731

Sigma factor

3 of 46

1.59

1.19

0.0026

KW-0805

Transcription regulation

6 of 331

1.04

0.93

0.00044

KW-0238

DNA-binding

7 of 452

0.97

0.9

0.00020

KW-0808

Transferase

6 of 752

0.68

0.43

0.0218

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02805

Metal binding domain of Ada

3 of 3

2.78

2.34

5.07e-05

PF00140

Sigma-70 factor, region 1.2

2 of 2

2.78

1.34

0.0037

PF04545

Sigma-70, region 4

3 of 24

1.88

1.23

0.0036

PF04539

Sigma-70 region 3

2 of 6

2.3

1.09

0.0098

PF01035

6-O-methylguanine DNA methyltransferase, DNA binding domain

2 of 5

2.38

1.09

0.0098

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR037046

DNA-3-methyladenine glycosylase AlkA, N-terminal domain superfamily

3 of 3

2.78

2.12

0.00013

IPR035451

Ada-like domain superfamily

3 of 3

2.78

2.12

0.00013

IPR010316

DNA-3-methyladenine glycosylase AlkA, N-terminal

3 of 3

2.78

2.12

0.00013

IPR004026

Ada DNA repair, metal-binding

3 of 3

2.78

2.12

0.00013

IPR023170

Helix-hairpin-helix, base-excision DNA repair, C-terminal

3 of 5

2.56

2.1

0.00013

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01009

AlkA N-terminal domain

3 of 3

2.78

2.71

1.03e-05

SM00342

Helix_turn_helix, arabinose operon control protein

3 of 18

2.0

1.74

0.00034

SM00478

Endonuclease III

2 of 2

2.78

1.71

0.00076

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (14%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About