Hypma_007700 protein (Hypsizygus marmoreus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

Hypma_007700

Uncharacterized protein. (661 aa)

Predicted Functional Partners:

nuc-2

0.958

PHO85

0.923

CDC28

0.860

ku80

0.781

ATG1

0.705

mus-51

0.693

ligA

0.691

LIG4

0.691

tor2

0.611

rrp6

0.611

Your Current Organism:

Hypsizygus marmoreus

NCBI taxonomy Id: 39966
Other names: H. marmoreus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG1	CDC28	A0A369J584	A0A369JN24	Serine/threonine-protein kinase ATG1.	Cyclin-dependent kinase 1.	0.631
ATG1	Hypma_007700	A0A369J584	A0A369JUM3	Serine/threonine-protein kinase ATG1.	Uncharacterized protein.	0.705
ATG1	PHO85	A0A369J584	A0A369K660	Serine/threonine-protein kinase ATG1.	Negative regulator of the PHO system.	0.733
ATG1	rrp6	A0A369J584	A0A369J4H5	Serine/threonine-protein kinase ATG1.	Exosome complex exonuclease rrp6.	0.960
ATG1	tor2	A0A369J584	A0A369J175	Serine/threonine-protein kinase ATG1.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.993
CDC28	ATG1	A0A369JN24	A0A369J584	Cyclin-dependent kinase 1.	Serine/threonine-protein kinase ATG1.	0.631
CDC28	Hypma_007700	A0A369JN24	A0A369JUM3	Cyclin-dependent kinase 1.	Uncharacterized protein.	0.860
CDC28	mus-51	A0A369JN24	A0A369K5E7	Cyclin-dependent kinase 1.	ATP-dependent DNA helicase II subunit 1.	0.576
CDC28	nuc-2	A0A369JN24	A0A369JM82	Cyclin-dependent kinase 1.	Ankyrin repeat protein nuc-2.	0.980
Hypma_007700	ATG1	A0A369JUM3	A0A369J584	Uncharacterized protein.	Serine/threonine-protein kinase ATG1.	0.705
Hypma_007700	CDC28	A0A369JUM3	A0A369JN24	Uncharacterized protein.	Cyclin-dependent kinase 1.	0.860
Hypma_007700	LIG4	A0A369JUM3	A0A369JT52	Uncharacterized protein.	DNA ligase.	0.691
Hypma_007700	PHO85	A0A369JUM3	A0A369K660	Uncharacterized protein.	Negative regulator of the PHO system.	0.923
Hypma_007700	ku80	A0A369JUM3	A0A369KBB1	Uncharacterized protein.	ATP-dependent DNA helicase II subunit 2.	0.781
Hypma_007700	ligA	A0A369JUM3	A0A369JD65	Uncharacterized protein.	DNA ligase.	0.691
Hypma_007700	mus-51	A0A369JUM3	A0A369K5E7	Uncharacterized protein.	ATP-dependent DNA helicase II subunit 1.	0.693
Hypma_007700	nuc-2	A0A369JUM3	A0A369JM82	Uncharacterized protein.	Ankyrin repeat protein nuc-2.	0.958
Hypma_007700	rrp6	A0A369JUM3	A0A369J4H5	Uncharacterized protein.	Exosome complex exonuclease rrp6.	0.611
Hypma_007700	tor2	A0A369JUM3	A0A369J175	Uncharacterized protein.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.611
LIG4	Hypma_007700	A0A369JT52	A0A369JUM3	DNA ligase.	Uncharacterized protein.	0.691

page 1 of 4

Network Stats

number of nodes:

4

number of edges:

3

average node degree:

1.5

avg. local clustering coefficient:

0.75

expected number of edges:

3

PPI enrichment p-value:

0.569

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0097525

Spliceosomal snRNP complex

3 of 39

1.79

1.1

0.0064

GO:0005685

U1 snRNP

2 of 9

2.25

1.03

0.0121

GO:0071944

Cell periphery

8 of 757

0.92

0.82

0.00033

GO:0031012

Extracellular matrix

2 of 19

1.92

0.76

0.0362

GO:0005681

Spliceosomal complex

3 of 105

1.36

0.67

0.0362

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5232

U2 snRNP, and U1 snRNP

3 of 22

2.03

1.2

0.0049

CL:7828

CS/DS degradation, and UVR domain

2 of 5

2.5

1.14

0.0083

CL:5235

U1 snRNP

2 of 6

2.42

1.13

0.0083

CL:5201

mRNA Splicing, and Leucine rich repeat N-terminal domain

4 of 132

1.38

0.9

0.0083

CL:1087

Mixed, incl. EGF domain, unclasssified subfamily, and FG-GAP repeat

2 of 21

1.88

0.82

0.0276

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2024101

CS/DS degradation

2 of 4

2.6

0.94

0.0197

MAP-77588

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

2 of 7

2.36

0.89

0.0236

MAP-111367

SLBP independent Processing of Histone Pre-mRNAs

2 of 8

2.3

0.88

0.0236

MAP-1793185

Chondroitin sulfate/dermatan sulfate metabolism

2 of 11

2.16

0.86

0.0255

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0508

mRNA splicing

2 of 10

2.2

0.9

0.0214

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR009030

Growth factor receptor cysteine-rich domain superfamily

5 of 166

1.38

1.03

0.0033

IPR001879

GPCR, family 2, extracellular hormone receptor domain

2 of 3

2.72

1.02

0.0140

IPR006212

Furin-like repeat

4 of 102

1.49

0.94

0.0092

IPR000832

GPCR, family 2, secretin-like

2 of 7

2.36

0.78

0.0377

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00261

Furin-like repeats

3 of 38

1.8

1.12

0.0058

SM00303

G-protein-coupled receptor proteolytic site domain

2 of 10

2.2

0.94

0.0179

SM00651

snRNP Sm proteins

2 of 13

2.09

0.92

0.0189

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