Hypma_007434 protein (Hypsizygus marmoreus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

Hypma_007434

Uncharacterized protein. (1007 aa)

Predicted Functional Partners:

srfA

0.567

sfh1

0.550

Hypma_015769

0.505

URBS1_1

0.457

OPI1

0.457

Hypma_001284

0.457

Hypma_003437

0.457

Hypma_002583

0.457

Hypma_012908

0.457

Hypma_014500

0.457

Your Current Organism:

Hypsizygus marmoreus

NCBI taxonomy Id: 39966
Other names: H. marmoreus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Hypma_001284	Hypma_007434	A0A369J8I1	A0A369JZ22	GATA-type domain-containing protein.	Uncharacterized protein.	0.457
Hypma_001284	Hypma_012908	A0A369J8I1	A0A369JCZ0	GATA-type domain-containing protein.	GATA-type domain-containing protein.	0.548
Hypma_001284	srfA	A0A369J8I1	A0A369JEC1	GATA-type domain-containing protein.	Serum response factor A.	0.706
Hypma_002583	Hypma_007434	A0A369JC13	A0A369JZ22	GATA-type domain-containing protein.	Uncharacterized protein.	0.457
Hypma_002583	Hypma_012908	A0A369JC13	A0A369JCZ0	GATA-type domain-containing protein.	GATA-type domain-containing protein.	0.638
Hypma_002583	srfA	A0A369JC13	A0A369JEC1	GATA-type domain-containing protein.	Serum response factor A.	0.706
Hypma_003437	Hypma_007434	A0A369J8L0	A0A369JZ22	Uncharacterized protein.	Uncharacterized protein.	0.457
Hypma_003437	srfA	A0A369J8L0	A0A369JEC1	Uncharacterized protein.	Serum response factor A.	0.514
Hypma_007434	Hypma_001284	A0A369JZ22	A0A369J8I1	Uncharacterized protein.	GATA-type domain-containing protein.	0.457
Hypma_007434	Hypma_002583	A0A369JZ22	A0A369JC13	Uncharacterized protein.	GATA-type domain-containing protein.	0.457
Hypma_007434	Hypma_003437	A0A369JZ22	A0A369J8L0	Uncharacterized protein.	Uncharacterized protein.	0.457
Hypma_007434	Hypma_012908	A0A369JZ22	A0A369JCZ0	Uncharacterized protein.	GATA-type domain-containing protein.	0.457
Hypma_007434	Hypma_014500	A0A369JZ22	A0A369JEK2	Uncharacterized protein.	Uncharacterized protein.	0.457
Hypma_007434	Hypma_015769	A0A369JZ22	A0A369KC37	Uncharacterized protein.	Uncharacterized protein.	0.505
Hypma_007434	OPI1	A0A369JZ22	A0A369J3K0	Uncharacterized protein.	Transcriptional repressor OPI1.	0.457
Hypma_007434	URBS1_1	A0A369JZ22	A0A151VEW7	Uncharacterized protein.	Siderophore biosynthesis regulatory protein URBS1.	0.457
Hypma_007434	sfh1	A0A369JZ22	A0A369J7F6	Uncharacterized protein.	Chromatin structure-remodeling complex subunit sfh1.	0.550
Hypma_007434	srfA	A0A369JZ22	A0A369JEC1	Uncharacterized protein.	Serum response factor A.	0.567
Hypma_012908	Hypma_001284	A0A369JCZ0	A0A369J8I1	GATA-type domain-containing protein.	GATA-type domain-containing protein.	0.548
Hypma_012908	Hypma_002583	A0A369JCZ0	A0A369JC13	GATA-type domain-containing protein.	GATA-type domain-containing protein.	0.638

page 1 of 3

Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006906

Vesicle fusion

7 of 29

2.23

5.08

9.03e-12

GO:0048284

Organelle fusion

8 of 47

2.08

4.94

2.04e-12

GO:0016050

Vesicle organization

8 of 50

2.05

4.86

2.04e-12

GO:0048278

Vesicle docking

4 of 18

2.19

2.75

3.13e-06

GO:0048193

Golgi vesicle transport

7 of 133

1.57

2.44

6.94e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000149

SNARE binding

5 of 27

2.11

3.01

5.62e-07

GO:0005484

SNAP receptor activity

3 of 20

2.02

1.34

0.0026

GO:0030674

Protein-macromolecule adaptor activity

4 of 86

1.51

1.15

0.0026

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005768

Endosome

6 of 121

1.54

2.17

7.36e-07

GO:0000139

Golgi membrane

5 of 85

1.62

2.04

7.24e-06

GO:0005794

Golgi apparatus

7 of 200

1.39

1.91

5.25e-07

GO:0031201

SNARE complex

3 of 18

2.07

1.89

0.00018

GO:0010008

Endosome membrane

4 of 53

1.72

1.85

6.57e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6105

Intra-Golgi and retrograde Golgi-to-ER traffic, and Organelle fusion

9 of 101

1.8

4.09

1.22e-12

CL:6237

Mixed, incl. HOPS complex, and RAB geranylgeranylation

5 of 35

2.0

2.94

4.25e-07

CL:6238

Mixed, incl. HOPS complex, and Mon1-Ccz1 complex

4 of 19

2.17

2.64

5.09e-06

CL:6113

SNARE, and CDC48, domain 2

3 of 6

2.54

2.4

3.34e-05

CL:6109

Retrograde transport at the Trans-Golgi-Network, and SNAP receptor activity

4 of 30

1.97

2.23

2.20e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04138

Autophagy - yeast

5 of 91

1.59

1.9

1.67e-05

map04130

SNARE interactions in vesicular transport

3 of 23

1.96

1.77

0.00026

map04144

Endocytosis

5 of 147

1.38

1.46

8.31e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6811442

Intra-Golgi and retrograde Golgi-to-ER traffic

6 of 95

1.65

2.26

1.71e-06

MAP-6811440

Retrograde transport at the Trans-Golgi-Network

4 of 37

1.88

1.9

9.96e-05

MAP-6811438

Intra-Golgi traffic

3 of 21

2.0

1.57

0.00078

MAP-199991

Membrane Trafficking

6 of 244

1.24

1.25

0.00013

MAP-5653656

Vesicle-mediated transport

6 of 246

1.23

1.24

0.00013

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0012505

Endomembrane system

7 of 577

0.93

0.71

0.0032

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00995

Sec1 family

2 of 5

2.45

0.83

0.0310

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR010989

SNARE

3 of 6

2.54

1.83

0.00041

IPR000727

Target SNARE coiled-coil homology domain

3 of 10

2.32

1.68

0.00070

IPR045242

Syntaxin

2 of 5

2.45

0.84

0.0296

IPR036045

Sec1-like superfamily

2 of 5

2.45

0.84

0.0296

IPR027482

Sec1-like, domain 2

2 of 5

2.45

0.84

0.0296

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00397

Helical region found in SNAREs

3 of 9

2.37

2.06

0.00013

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