EIF1AX protein (Hypsizygus marmoreus) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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gene co-occurrence

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protein homology

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EIF1AX

Eukaryotic translation initiation factor 1A, X-chromosomal; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (143 aa)

Predicted Functional Partners:

RPS15

0.999

crp-28

0.999

rps20

0.999

Rps3

0.999

RPS29

0.999

rps2

0.998

RPS0

0.998

SUI1A

0.998

Hypma_015542

0.998

RPS13

0.997

Your Current Organism:

Hypsizygus marmoreus

NCBI taxonomy Id: 39966
Other names: H. marmoreus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF1AX	Hypma_015542	A0A369K137	A0A369K6L6	Eukaryotic translation initiation factor 1A, X-chromosomal; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	40S ribosomal protein S11-B; Belongs to the universal ribosomal protein uS17 family.	0.998
EIF1AX	RPS0	A0A369K137	A0A369JR16	Eukaryotic translation initiation factor 1A, X-chromosomal; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	40S ribosomal protein S0; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.	0.998
EIF1AX	RPS13	A0A369K137	A0A369J4J8	Eukaryotic translation initiation factor 1A, X-chromosomal; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	40S ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family.	0.997
EIF1AX	RPS15	A0A369K137	A0A369JN97	Eukaryotic translation initiation factor 1A, X-chromosomal; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	40S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.999
EIF1AX	RPS29	A0A369K137	A0A369K6L4	Eukaryotic translation initiation factor 1A, X-chromosomal; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	40S ribosomal protein S29.	0.999
EIF1AX	Rps3	A0A369K137	A0A369K4W2	Eukaryotic translation initiation factor 1A, X-chromosomal; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family.	0.999
EIF1AX	SUI1A	A0A369K137	A0A369JUC8	Eukaryotic translation initiation factor 1A, X-chromosomal; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	Protein translation factor SUI1.	0.998
EIF1AX	crp-28	A0A369K137	A0A369JX42	Eukaryotic translation initiation factor 1A, X-chromosomal; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	40S ribosomal protein S23.	0.999
EIF1AX	rps2	A0A369K137	A0A369JDR1	Eukaryotic translation initiation factor 1A, X-chromosomal; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	40S ribosomal protein S2; Belongs to the universal ribosomal protein uS5 family.	0.998
EIF1AX	rps20	A0A369K137	A0A369JXI5	Eukaryotic translation initiation factor 1A, X-chromosomal; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	40S ribosomal protein S20.	0.999
Hypma_015542	EIF1AX	A0A369K6L6	A0A369K137	40S ribosomal protein S11-B; Belongs to the universal ribosomal protein uS17 family.	Eukaryotic translation initiation factor 1A, X-chromosomal; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	0.998
Hypma_015542	RPS0	A0A369K6L6	A0A369JR16	40S ribosomal protein S11-B; Belongs to the universal ribosomal protein uS17 family.	40S ribosomal protein S0; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.	0.999
Hypma_015542	RPS13	A0A369K6L6	A0A369J4J8	40S ribosomal protein S11-B; Belongs to the universal ribosomal protein uS17 family.	40S ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family.	0.999
Hypma_015542	RPS15	A0A369K6L6	A0A369JN97	40S ribosomal protein S11-B; Belongs to the universal ribosomal protein uS17 family.	40S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.999
Hypma_015542	RPS29	A0A369K6L6	A0A369K6L4	40S ribosomal protein S11-B; Belongs to the universal ribosomal protein uS17 family.	40S ribosomal protein S29.	0.999
Hypma_015542	Rps3	A0A369K6L6	A0A369K4W2	40S ribosomal protein S11-B; Belongs to the universal ribosomal protein uS17 family.	40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family.	0.999
Hypma_015542	SUI1A	A0A369K6L6	A0A369JUC8	40S ribosomal protein S11-B; Belongs to the universal ribosomal protein uS17 family.	Protein translation factor SUI1.	0.984
Hypma_015542	crp-28	A0A369K6L6	A0A369JX42	40S ribosomal protein S11-B; Belongs to the universal ribosomal protein uS17 family.	40S ribosomal protein S23.	0.999
Hypma_015542	rps2	A0A369K6L6	A0A369JDR1	40S ribosomal protein S11-B; Belongs to the universal ribosomal protein uS17 family.	40S ribosomal protein S2; Belongs to the universal ribosomal protein uS5 family.	0.999
Hypma_015542	rps20	A0A369K6L6	A0A369JXI5	40S ribosomal protein S11-B; Belongs to the universal ribosomal protein uS17 family.	40S ribosomal protein S20.	0.999

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Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.565

expected number of edges:

13

PPI enrichment p-value:

1.46e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019774

Proteasome core complex, beta-subunit complex

2 of 15

2.49

0.94

0.0190

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:46819

Mostly uncharacterized, incl. Domain of unknown function (DUF4408), and acyl-CoA hydrolase activity

6 of 36

2.59

5.39

3.05e-11

CL:46822

Mixed, incl. Domain of unknown function (DUF4408), and acyl-CoA hydrolase activity

5 of 16

2.86

5.13

2.54e-10

CL:46824

acyl-CoA hydrolase activity, and Domain of unknown function (DUF4408)

3 of 5

3.15

3.02

3.30e-06

CL:16392

Siderophore metabolic process, and Aldo/keto reductase family

2 of 11

2.63

1.08

0.0109

CL:8159

Proteasome subunit

2 of 25

2.27

0.78

0.0367

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016006

Nebenkern

2 of 2

3.37

1.59

0.0014

GOCC:0019774

Proteasome core complex, beta-subunit complex

2 of 15

2.49

0.99

0.0154

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0888

Threonine protease

2 of 29

2.21

0.87

0.0245

KW-0407

Ion channel

2 of 50

1.97

0.77

0.0348

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