Hypma_004419 protein (Hypsizygus marmoreus) - STRING interaction network

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

Hypma_004419

Uncharacterized protein. (432 aa)

Predicted Functional Partners:

dmc1

0.717

wdr61

0.715

rad50

0.694

rhp51

0.683

MRE11

0.674

XRCC3

0.637

Rad51c

0.623

Rad51d

0.623

rad16

0.555

Hypma_015537

0.542

Your Current Organism:

Hypsizygus marmoreus

NCBI taxonomy Id: 39966
Other names: H. marmoreus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Hypma_004419	Hypma_015537	A0A369K8F6	A0A369K5C4	Uncharacterized protein.	Rad21_Rec8_N domain-containing protein.	0.542
Hypma_004419	MRE11	A0A369K8F6	A0A369JBG3	Uncharacterized protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.674
Hypma_004419	Rad51c	A0A369K8F6	A0A369K5C0	Uncharacterized protein.	DNA repair protein RAD51 3.	0.623
Hypma_004419	Rad51d	A0A369K8F6	A0A369KBN2	Uncharacterized protein.	DNA repair protein RAD51 4.	0.623
Hypma_004419	XRCC3	A0A369K8F6	A0A369JSG8	Uncharacterized protein.	DNA repair protein XRCC3.	0.637
Hypma_004419	dmc1	A0A369K8F6	A0A369K464	Uncharacterized protein.	Meiotic recombination protein dmc1; Belongs to the RecA family.	0.717
Hypma_004419	rad16	A0A369K8F6	A0A369K0Q6	Uncharacterized protein.	DNA repair protein rad16.	0.555
Hypma_004419	rad50	A0A369K8F6	A0A369J7H5	Uncharacterized protein.	DNA repair protein rad50.	0.694
Hypma_004419	rhp51	A0A369K8F6	A0A369KFE5	Uncharacterized protein.	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	0.683
Hypma_004419	wdr61	A0A369K8F6	A0A369JG86	Uncharacterized protein.	WD repeat-containing protein 61.	0.715
Hypma_015537	Hypma_004419	A0A369K5C4	A0A369K8F6	Rad21_Rec8_N domain-containing protein.	Uncharacterized protein.	0.542
Hypma_015537	dmc1	A0A369K5C4	A0A369K464	Rad21_Rec8_N domain-containing protein.	Meiotic recombination protein dmc1; Belongs to the RecA family.	0.589
Hypma_015537	rad16	A0A369K5C4	A0A369K0Q6	Rad21_Rec8_N domain-containing protein.	DNA repair protein rad16.	0.482
Hypma_015537	wdr61	A0A369K5C4	A0A369JG86	Rad21_Rec8_N domain-containing protein.	WD repeat-containing protein 61.	0.426
MRE11	Hypma_004419	A0A369JBG3	A0A369K8F6	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Uncharacterized protein.	0.674
MRE11	Rad51c	A0A369JBG3	A0A369K5C0	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	DNA repair protein RAD51 3.	0.881
MRE11	Rad51d	A0A369JBG3	A0A369KBN2	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	DNA repair protein RAD51 4.	0.916
MRE11	XRCC3	A0A369JBG3	A0A369JSG8	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	DNA repair protein XRCC3.	0.897
MRE11	dmc1	A0A369JBG3	A0A369K464	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Meiotic recombination protein dmc1; Belongs to the RecA family.	0.862
MRE11	rad16	A0A369JBG3	A0A369K0Q6	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	DNA repair protein rad16.	0.850

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Network Stats

number of nodes:

11

number of edges:

52

average node degree:

9.45

avg. local clustering coefficient:

0.939

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006869

Lipid transport

6 of 12

2.48

5.02

1.05e-10

GO:0051701

Biological process involved in interaction with host

5 of 66

1.66

2.04

1.11e-05

GO:0070508

Cholesterol import

2 of 2

2.78

1.46

0.0022

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005548

Phospholipid transporter activity

4 of 4

2.78

3.56

2.44e-07

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043190

ATP-binding cassette (ABC) transporter complex

4 of 49

1.69

1.68

0.00017

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8016

Mce/MlaD, and Permease MlaE

11 of 19

2.54

10.76

2.85e-24

CL:8017

Mce/MlaD, and Permease MlaE

8 of 10

2.68

8.39

1.84e-17

CL:8021

Mce/MlaD, and Sterol transport

5 of 5

2.78

5.12

2.21e-10

CL:8039

Phospholipid transport, and Sterol transport

3 of 5

2.56

2.4

3.38e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02010

ABC transporters

11 of 318

1.32

2.34

5.42e-13

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9635465

Suppression of apoptosis

5 of 21

2.16

3.82

7.80e-09

MAP-9637690

Response of Mtb to phagocytosis

5 of 103

1.47

1.84

6.21e-06

MAP-9635486

Infection with Mycobacterium tuberculosis

5 of 258

1.07

0.98

0.00033

MAP-5663205

Infectious disease

5 of 259

1.07

0.98

0.00033

MAP-1643685

Disease

5 of 267

1.05

0.97

0.00033

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990351

Transporter complex

6 of 77

1.67

2.45

4.61e-07

GOCC:1990531

Phospholipid-translocating ATPase complex

2 of 2

2.78

1.69

0.00082

GOCC:0043190

ATP-binding cassette (ABC) transporter complex

4 of 63

1.58

1.44

0.00049

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02470

MlaD protein

5 of 12

2.4

3.91

1.98e-08

PF02405

Permease MlaE

4 of 4

2.78

3.75

1.07e-07

PF11887

Cholesterol uptake porter CUP1 of Mce4, putative

2 of 3

2.6

1.21

0.0062

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR024516

Mammalian cell entry, C-terminal

5 of 12

2.4

3.72

4.97e-08

IPR005693

Virulence factor Mce protein

5 of 12

2.4

3.72

4.97e-08

IPR003399

Mce/MlaD

5 of 12

2.4

3.72

4.97e-08

IPR030802

ABC transporter permease MalE

4 of 4

2.78

3.7

1.34e-07

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