STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
top2DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1586 aa)    
Predicted Functional Partners:
top1
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
   
 
 0.953
cut14
Structural maintenance of chromosomes protein.
   
 
 0.932
ubc11
Ubiquitin-conjugating enzyme E2; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.896
cut3
Structural maintenance of chromosomes protein 4.
   
 
 0.894
pli1
E3 SUMO-protein ligase pli1.
    
 0.865
cnd2
Condensin complex subunit 2.
   
 
 0.861
SMT3_1
Ubiquitin-like protein SMT3.
    
 0.851
SMT3_0
Ubiquitin-like protein SMT3.
    
 0.851
Hypma_015850
Uncharacterized protein.
    
 0.851
hus5_1
SUMO-conjugating enzyme ubc9; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.847
Your Current Organism:
Hypsizygus marmoreus
NCBI taxonomy Id: 39966
Other names: H. marmoreus
Server load: low (14%) [HD]