Hypma_013873 protein (Hypsizygus marmoreus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

Hypma_013873

Uncharacterized protein. (176 aa)

Predicted Functional Partners:

IPI3

0.812

TEX10

0.775

NOP7

0.739

ain1

0.686

ERB1

0.671

MYH11

0.632

GRC3

0.631

CMD1_1

0.627

cdc4

0.627

CMD1_0

0.627

Your Current Organism:

Hypsizygus marmoreus

NCBI taxonomy Id: 39966
Other names: H. marmoreus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CMD1_0	Hypma_013873	A0A369K6W1	A0A369KAX1	Calmodulin; Belongs to the calmodulin family.	Uncharacterized protein.	0.627
CMD1_0	MYH11	A0A369K6W1	A0A369JY59	Calmodulin; Belongs to the calmodulin family.	Myosin-11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.942
CMD1_0	ain1	A0A369K6W1	A0A369J7C1	Calmodulin; Belongs to the calmodulin family.	Alpha-actinin-like protein 1.	0.752
CMD1_0	cdc4	A0A369K6W1	A0A369K4J4	Calmodulin; Belongs to the calmodulin family.	Myosin regulatory light chain cdc4.	0.918
CMD1_1	Hypma_013873	A0A369K1Y0	A0A369KAX1	Calmodulin.	Uncharacterized protein.	0.627
CMD1_1	MYH11	A0A369K1Y0	A0A369JY59	Calmodulin.	Myosin-11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.942
CMD1_1	ain1	A0A369K1Y0	A0A369J7C1	Calmodulin.	Alpha-actinin-like protein 1.	0.752
CMD1_1	cdc4	A0A369K1Y0	A0A369K4J4	Calmodulin.	Myosin regulatory light chain cdc4.	0.920
ERB1	GRC3	A0A369JM51	A0A369JG30	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Polynucleotide 5'-hydroxyl-kinase GRC3.	0.821
ERB1	Hypma_013873	A0A369JM51	A0A369KAX1	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Uncharacterized protein.	0.671
ERB1	IPI3	A0A369JM51	A0A369JQC4	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Pre-rRNA-processing protein IPI3.	0.974
ERB1	NOP7	A0A369JM51	A0A369K8U8	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.999
ERB1	TEX10	A0A369JM51	A0A369KCC7	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Testis-expressed sequence 10 protein.	0.809
GRC3	ERB1	A0A369JG30	A0A369JM51	Polynucleotide 5'-hydroxyl-kinase GRC3.	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.821
GRC3	Hypma_013873	A0A369JG30	A0A369KAX1	Polynucleotide 5'-hydroxyl-kinase GRC3.	Uncharacterized protein.	0.631
GRC3	IPI3	A0A369JG30	A0A369JQC4	Polynucleotide 5'-hydroxyl-kinase GRC3.	Pre-rRNA-processing protein IPI3.	0.986
GRC3	NOP7	A0A369JG30	A0A369K8U8	Polynucleotide 5'-hydroxyl-kinase GRC3.	Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.693
GRC3	TEX10	A0A369JG30	A0A369KCC7	Polynucleotide 5'-hydroxyl-kinase GRC3.	Testis-expressed sequence 10 protein.	0.929
Hypma_013873	CMD1_0	A0A369KAX1	A0A369K6W1	Uncharacterized protein.	Calmodulin; Belongs to the calmodulin family.	0.627
Hypma_013873	CMD1_1	A0A369KAX1	A0A369K1Y0	Uncharacterized protein.	Calmodulin.	0.627

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Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.982

expected number of edges:

13

PPI enrichment p-value:

2.99e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042273

Ribosomal large subunit biogenesis

10 of 56

2.23

7.35

1.96e-18

GO:0000470

Maturation of LSU-rRNA

7 of 27

2.39

5.94

3.87e-13

GO:0000463

Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

5 of 20

2.37

4.07

7.49e-09

GO:0006364

rRNA processing

10 of 182

1.71

4.06

3.40e-14

GO:0042254

Ribosome biogenesis

11 of 246

1.63

3.81

2.93e-15

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

6 of 484

1.07

0.77

0.0058

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030687

Preribosome, large subunit precursor

6 of 25

2.36

4.8

1.50e-10

GO:0030684

Preribosome

7 of 72

1.96

4.06

1.50e-10

GO:0005730

Nucleolus

8 of 210

1.56

2.74

1.34e-09

GO:0005634

Nucleus

9 of 1888

0.65

0.54

0.00060

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5304

Ribosomal large subunit biogenesis, and CBF/Mak21 family

11 of 41

2.4

9.76

2.48e-23

CL:5307

Preribosome, large subunit precursor, and Maturation of LSU-rRNA

9 of 27

2.5

8.67

2.96e-19

CL:5316

Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and Ribosomal protein L1-like

5 of 7

2.83

5.57

3.31e-11

CL:5309

Preribosome, large subunit precursor, and Maturation of LSU-rRNA

6 of 22

2.41

5.39

9.62e-12

CL:5368

CBF/Mak21 family, and RNA helicase, DEAD-box type, Q motif

2 of 5

2.58

1.51

0.0017

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6791226

Major pathway of rRNA processing in the nucleolus and cytosol

5 of 105

1.65

1.83

4.93e-05

MAP-8868773

rRNA processing in the nucleus and cytosol

5 of 107

1.64

1.82

4.93e-05

MAP-72312

rRNA processing

5 of 111

1.63

1.8

4.93e-05

MAP-8953854

Metabolism of RNA

5 of 460

1.01

0.64

0.0150

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005730

Nucleolus

6 of 106

1.73

2.61

2.78e-07

GOCC:0031981

Nuclear lumen

9 of 473

1.25

1.75

4.30e-08

GOCC:0030688

Preribosome, small subunit precursor

2 of 11

2.23

1.1

0.0091

GOCC:0030684

Preribosome

3 of 64

1.65

1.09

0.0053

GOCC:0030687

Preribosome, large subunit precursor

2 of 21

1.95

0.92

0.0180

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0698

rRNA processing

2 of 14

2.13

0.84

0.0274

KW-0690

Ribosome biogenesis

2 of 17

2.05

0.83

0.0274

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