STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisHFImidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family. (562 aa)    
Predicted Functional Partners:
HIS3
Imidazoleglycerol-phosphate dehydratase.
 
 0.997
Hypma_010200
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase.
  
 
 0.997
HIS4
Histidine biosynthesis trifunctional protein.
 
 0.996
HIS1
ATP phosphoribosyltransferase.
 
 
 0.992
CIA1
Probable cytosolic iron-sulfur protein assembly protein 1; Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.
  
 
 0.989
rhp16
ATP-dependent helicase rhp16.
  
 
 0.965
ADE17
Bifunctional purine biosynthesis protein ADE17.
  
 
 0.937
APT1
Adenine phosphoribosyltransferase.
   
 
 0.918
ADE13
Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
    
 0.885
pnk1
Bifunctional polynucleotide phosphatase/kinase.
  
 
 0.873
Your Current Organism:
Hypsizygus marmoreus
NCBI taxonomy Id: 39966
Other names: H. marmoreus
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