| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SDH12153.1 | SDH18559.1 | SAMN04489720_0112 | SAMN04489720_0328 | 3-hydroxyacyl-CoA dehydrogenase. | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 0.443 |
| SDH12153.1 | SDH48164.1 | SAMN04489720_0112 | SAMN04489720_1389 | 3-hydroxyacyl-CoA dehydrogenase. | oxepin-CoA hydrolase / 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase. | 0.965 |
| SDH12153.1 | SDH77176.1 | SAMN04489720_0112 | SAMN04489720_2332 | 3-hydroxyacyl-CoA dehydrogenase. | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. | 0.959 |
| SDH12153.1 | SDH89834.1 | SAMN04489720_0112 | SAMN04489720_2774 | 3-hydroxyacyl-CoA dehydrogenase. | Citrate synthase; Belongs to the citrate synthase family. | 0.908 |
| SDH12153.1 | SDH92874.1 | SAMN04489720_0112 | SAMN04489720_2897 | 3-hydroxyacyl-CoA dehydrogenase. | Malate synthase; Belongs to the malate synthase family. | 0.796 |
| SDH12153.1 | SDH96301.1 | SAMN04489720_0112 | SAMN04489720_3017 | 3-hydroxyacyl-CoA dehydrogenase. | Malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase. | 0.881 |
| SDH12153.1 | SDH98977.1 | SAMN04489720_0112 | SAMN04489720_3110 | 3-hydroxyacyl-CoA dehydrogenase. | Citrate synthase; Belongs to the citrate synthase family. | 0.908 |
| SDH12153.1 | ackA | SAMN04489720_0112 | SAMN04489720_2333 | 3-hydroxyacyl-CoA dehydrogenase. | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. | 0.411 |
| SDH12153.1 | acsA | SAMN04489720_0112 | SAMN04489720_2351 | 3-hydroxyacyl-CoA dehydrogenase. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.941 |
| SDH18559.1 | SDH12153.1 | SAMN04489720_0328 | SAMN04489720_0112 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 3-hydroxyacyl-CoA dehydrogenase. | 0.443 |
| SDH18559.1 | SDH48164.1 | SAMN04489720_0328 | SAMN04489720_1389 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | oxepin-CoA hydrolase / 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase. | 0.727 |
| SDH18559.1 | SDH77176.1 | SAMN04489720_0328 | SAMN04489720_2332 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. | 0.919 |
| SDH18559.1 | SDH89834.1 | SAMN04489720_0328 | SAMN04489720_2774 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Citrate synthase; Belongs to the citrate synthase family. | 0.891 |
| SDH18559.1 | SDH92874.1 | SAMN04489720_0328 | SAMN04489720_2897 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Malate synthase; Belongs to the malate synthase family. | 0.910 |
| SDH18559.1 | SDH98977.1 | SAMN04489720_0328 | SAMN04489720_3110 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Citrate synthase; Belongs to the citrate synthase family. | 0.891 |
| SDH18559.1 | SDH99004.1 | SAMN04489720_0328 | SAMN04489720_3111 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. | 0.897 |
| SDH18559.1 | ackA | SAMN04489720_0328 | SAMN04489720_2333 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. | 0.731 |
| SDH18559.1 | acsA | SAMN04489720_0328 | SAMN04489720_2351 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.857 |
| SDH48164.1 | SDH12153.1 | SAMN04489720_1389 | SAMN04489720_0112 | oxepin-CoA hydrolase / 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase. | 3-hydroxyacyl-CoA dehydrogenase. | 0.965 |
| SDH48164.1 | SDH18559.1 | SAMN04489720_1389 | SAMN04489720_0328 | oxepin-CoA hydrolase / 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase. | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 0.727 |