| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SDH13500.1 | SDH55735.1 | SAMN04489720_0163 | SAMN04489720_1607 | Ribonuclease HI. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.630 |
| SDH13500.1 | SDH69421.1 | SAMN04489720_0163 | SAMN04489720_2046 | Ribonuclease HI. | ATP-dependent DNA helicase RecQ. | 0.528 |
| SDH13500.1 | SDH70383.1 | SAMN04489720_0163 | SAMN04489720_2080 | Ribonuclease HI. | ATP-dependent DNA helicase RecQ. | 0.528 |
| SDH13500.1 | SDH94127.1 | SAMN04489720_0163 | SAMN04489720_2946 | Ribonuclease HI. | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.898 |
| SDH13500.1 | polA | SAMN04489720_0163 | SAMN04489720_0035 | Ribonuclease HI. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.968 |
| SDH13500.1 | thyA | SAMN04489720_0163 | SAMN04489720_0469 | Ribonuclease HI. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.633 |
| SDH55735.1 | SDH13500.1 | SAMN04489720_1607 | SAMN04489720_0163 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ribonuclease HI. | 0.630 |
| SDH55735.1 | SDH69421.1 | SAMN04489720_1607 | SAMN04489720_2046 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | ATP-dependent DNA helicase RecQ. | 0.795 |
| SDH55735.1 | SDH70383.1 | SAMN04489720_1607 | SAMN04489720_2080 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | ATP-dependent DNA helicase RecQ. | 0.795 |
| SDH55735.1 | SDH81024.1 | SAMN04489720_1607 | SAMN04489720_2463 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA topoisomerase-1. | 0.547 |
| SDH55735.1 | SDH94127.1 | SAMN04489720_1607 | SAMN04489720_2946 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.945 |
| SDH55735.1 | polA | SAMN04489720_1607 | SAMN04489720_0035 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.999 |
| SDH55735.1 | thyA | SAMN04489720_1607 | SAMN04489720_0469 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.788 |
| SDH69421.1 | SDH13500.1 | SAMN04489720_2046 | SAMN04489720_0163 | ATP-dependent DNA helicase RecQ. | Ribonuclease HI. | 0.528 |
| SDH69421.1 | SDH55735.1 | SAMN04489720_2046 | SAMN04489720_1607 | ATP-dependent DNA helicase RecQ. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.795 |
| SDH69421.1 | SDH81024.1 | SAMN04489720_2046 | SAMN04489720_2463 | ATP-dependent DNA helicase RecQ. | DNA topoisomerase-1. | 0.831 |
| SDH69421.1 | SDH94127.1 | SAMN04489720_2046 | SAMN04489720_2946 | ATP-dependent DNA helicase RecQ. | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.766 |
| SDH69421.1 | polA | SAMN04489720_2046 | SAMN04489720_0035 | ATP-dependent DNA helicase RecQ. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.966 |
| SDH70383.1 | SDH13500.1 | SAMN04489720_2080 | SAMN04489720_0163 | ATP-dependent DNA helicase RecQ. | Ribonuclease HI. | 0.528 |
| SDH70383.1 | SDH55735.1 | SAMN04489720_2080 | SAMN04489720_1607 | ATP-dependent DNA helicase RecQ. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.795 |