STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
selUtRNA 2-selenouridine synthase; Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2- selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain. (373 aa)    
Predicted Functional Partners:
selD
Selenophosphate synthase; Synthesizes selenophosphate from selenide and ATP.
 
   
 0.967
mnmC
Protein of unknown function DUF752; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family.
  
  
 0.717
Pmen_2453
Hypothetical protein.
       0.687
Pmen_2452
Conserved protein/domain typically associated with flavoprotein oxygenase DIM6/NTAB family-like protein.
       0.686
Pmen_2456
PFAM: Patatin.
       0.597
Pmen_4368
PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase.
 
   
 0.521
thiI
[ThiS-adenylate] sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
   
 0.451
Pmen_2451
PFAM: histidine kinase, HAMP region domain protein; chemotaxis sensory transducer.
       0.429
Your Current Organism:
Pseudomonas mendocina ymp
NCBI taxonomy Id: 399739
Other names: P. mendocina ymp, Pseudomonas mendocina str. ymp, Pseudomonas mendocina strain ymp
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