node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Spro_0472 | Spro_1079 | Spro_0472 | Spro_1079 | PFAM: Polyprenyl synthetase; KEGG: eca:ECA0689 octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | PFAM: Polyprenyl synthetase; KEGG: yen:YE3154 geranyltranstransferase; Belongs to the FPP/GGPP synthase family. | 0.926 |
Spro_0472 | Spro_2865 | Spro_0472 | Spro_2865 | PFAM: Polyprenyl synthetase; KEGG: eca:ECA0689 octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | KEGG: eca:ECA0113 hypothetical protein. | 0.610 |
Spro_0472 | Spro_3331 | Spro_0472 | Spro_3331 | PFAM: Polyprenyl synthetase; KEGG: eca:ECA0689 octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | FolC bifunctional protein; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | 0.530 |
Spro_0472 | Spro_4344 | Spro_0472 | Spro_4344 | PFAM: Polyprenyl synthetase; KEGG: eca:ECA0689 octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: yen:YE3735 glutamate synthase [NADPH] large chain precursor. | 0.506 |
Spro_0472 | menA | Spro_0472 | Spro_4794 | PFAM: Polyprenyl synthetase; KEGG: eca:ECA0689 octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | 0.847 |
Spro_0472 | ndk | Spro_0472 | Spro_3613 | PFAM: Polyprenyl synthetase; KEGG: eca:ECA0689 octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.557 |
Spro_0472 | ubiA | Spro_0472 | Spro_4463 | PFAM: Polyprenyl synthetase; KEGG: eca:ECA0689 octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 4-hydroxybenzoate polyprenyl transferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.907 |
Spro_0472 | ubiG | Spro_0472 | Spro_3270 | PFAM: Polyprenyl synthetase; KEGG: eca:ECA0689 octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Ubiquinone biosynthesis O-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. | 0.534 |
Spro_0472 | uppS | Spro_0472 | Spro_3785 | PFAM: Polyprenyl synthetase; KEGG: eca:ECA0689 octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Undecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.968 |
Spro_0472 | xseB | Spro_0472 | Spro_1080 | PFAM: Polyprenyl synthetase; KEGG: eca:ECA0689 octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Exodeoxyribonuclease VII, small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. | 0.570 |
Spro_1079 | Spro_0472 | Spro_1079 | Spro_0472 | PFAM: Polyprenyl synthetase; KEGG: yen:YE3154 geranyltranstransferase; Belongs to the FPP/GGPP synthase family. | PFAM: Polyprenyl synthetase; KEGG: eca:ECA0689 octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 0.926 |
Spro_1079 | Spro_2865 | Spro_1079 | Spro_2865 | PFAM: Polyprenyl synthetase; KEGG: yen:YE3154 geranyltranstransferase; Belongs to the FPP/GGPP synthase family. | KEGG: eca:ECA0113 hypothetical protein. | 0.610 |
Spro_1079 | Spro_4344 | Spro_1079 | Spro_4344 | PFAM: Polyprenyl synthetase; KEGG: yen:YE3154 geranyltranstransferase; Belongs to the FPP/GGPP synthase family. | PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: yen:YE3735 glutamate synthase [NADPH] large chain precursor. | 0.506 |
Spro_1079 | ndk | Spro_1079 | Spro_3613 | PFAM: Polyprenyl synthetase; KEGG: yen:YE3154 geranyltranstransferase; Belongs to the FPP/GGPP synthase family. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.561 |
Spro_1079 | uppS | Spro_1079 | Spro_3785 | PFAM: Polyprenyl synthetase; KEGG: yen:YE3154 geranyltranstransferase; Belongs to the FPP/GGPP synthase family. | Undecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.969 |
Spro_1079 | xseB | Spro_1079 | Spro_1080 | PFAM: Polyprenyl synthetase; KEGG: yen:YE3154 geranyltranstransferase; Belongs to the FPP/GGPP synthase family. | Exodeoxyribonuclease VII, small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. | 0.915 |
Spro_2865 | Spro_0472 | Spro_2865 | Spro_0472 | KEGG: eca:ECA0113 hypothetical protein. | PFAM: Polyprenyl synthetase; KEGG: eca:ECA0689 octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 0.610 |
Spro_2865 | Spro_1079 | Spro_2865 | Spro_1079 | KEGG: eca:ECA0113 hypothetical protein. | PFAM: Polyprenyl synthetase; KEGG: yen:YE3154 geranyltranstransferase; Belongs to the FPP/GGPP synthase family. | 0.610 |
Spro_2865 | ubiA | Spro_2865 | Spro_4463 | KEGG: eca:ECA0113 hypothetical protein. | 4-hydroxybenzoate polyprenyl transferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.503 |
Spro_3331 | Spro_0472 | Spro_3331 | Spro_0472 | FolC bifunctional protein; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | PFAM: Polyprenyl synthetase; KEGG: eca:ECA0689 octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 0.530 |