| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Spro_0212 | Spro_4134 | Spro_0212 | Spro_4134 | PFAM: YhhN family protein; KEGG: yen:YE0219 hypothetical protein. | Transcriptional regulator, CadC; PFAM: transcriptional regulator domain protein; KEGG: eca:ECA0944 hypothetical protein. | 0.491 |
| Spro_0212 | Spro_4726 | Spro_0212 | Spro_4726 | PFAM: YhhN family protein; KEGG: yen:YE0219 hypothetical protein. | Transcriptional regulator, CadC; PFAM: transcriptional regulator domain protein; KEGG: eca:ECA0944 hypothetical protein. | 0.590 |
| Spro_0212 | arnE | Spro_0212 | Spro_2159 | PFAM: YhhN family protein; KEGG: yen:YE0219 hypothetical protein. | Conserved hypothetical protein; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnE family. | 0.599 |
| Spro_0212 | arnF | Spro_0212 | Spro_2160 | PFAM: YhhN family protein; KEGG: yen:YE0219 hypothetical protein. | Conserved hypothetical protein; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnF family. | 0.548 |
| Spro_0212 | wzzE | Spro_0212 | Spro_0162 | PFAM: YhhN family protein; KEGG: yen:YE0219 hypothetical protein. | Lipopolysaccharide biosynthesis protein; Modulates the polysaccharide chain length of enterobacterial common antigen (ECA); Belongs to the WzzB/Cld/Rol family. | 0.477 |
| Spro_4134 | Spro_0212 | Spro_4134 | Spro_0212 | Transcriptional regulator, CadC; PFAM: transcriptional regulator domain protein; KEGG: eca:ECA0944 hypothetical protein. | PFAM: YhhN family protein; KEGG: yen:YE0219 hypothetical protein. | 0.491 |
| Spro_4134 | arnE | Spro_4134 | Spro_2159 | Transcriptional regulator, CadC; PFAM: transcriptional regulator domain protein; KEGG: eca:ECA0944 hypothetical protein. | Conserved hypothetical protein; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnE family. | 0.666 |
| Spro_4134 | arnF | Spro_4134 | Spro_2160 | Transcriptional regulator, CadC; PFAM: transcriptional regulator domain protein; KEGG: eca:ECA0944 hypothetical protein. | Conserved hypothetical protein; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnF family. | 0.645 |
| Spro_4134 | wzzE | Spro_4134 | Spro_0162 | Transcriptional regulator, CadC; PFAM: transcriptional regulator domain protein; KEGG: eca:ECA0944 hypothetical protein. | Lipopolysaccharide biosynthesis protein; Modulates the polysaccharide chain length of enterobacterial common antigen (ECA); Belongs to the WzzB/Cld/Rol family. | 0.442 |
| Spro_4726 | Spro_0212 | Spro_4726 | Spro_0212 | Transcriptional regulator, CadC; PFAM: transcriptional regulator domain protein; KEGG: eca:ECA0944 hypothetical protein. | PFAM: YhhN family protein; KEGG: yen:YE0219 hypothetical protein. | 0.590 |
| Spro_4726 | arnE | Spro_4726 | Spro_2159 | Transcriptional regulator, CadC; PFAM: transcriptional regulator domain protein; KEGG: eca:ECA0944 hypothetical protein. | Conserved hypothetical protein; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnE family. | 0.670 |
| Spro_4726 | arnF | Spro_4726 | Spro_2160 | Transcriptional regulator, CadC; PFAM: transcriptional regulator domain protein; KEGG: eca:ECA0944 hypothetical protein. | Conserved hypothetical protein; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnF family. | 0.467 |
| Spro_4726 | wzzE | Spro_4726 | Spro_0162 | Transcriptional regulator, CadC; PFAM: transcriptional regulator domain protein; KEGG: eca:ECA0944 hypothetical protein. | Lipopolysaccharide biosynthesis protein; Modulates the polysaccharide chain length of enterobacterial common antigen (ECA); Belongs to the WzzB/Cld/Rol family. | 0.565 |
| arnA | arnB | Spro_2156 | Spro_2154 | NAD-dependent epimerase/dehydratase; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. | DegT/DnrJ/EryC1/StrS aminotransferase; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. | 0.997 |
| arnA | arnC | Spro_2156 | Spro_2155 | NAD-dependent epimerase/dehydratase; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. | Glycosyl transferase family 2; Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. | 0.999 |
| arnA | arnD | Spro_2156 | Spro_2157 | NAD-dependent epimerase/dehydratase; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. | Polysaccharide deacetylase; Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily. | 0.992 |
| arnA | arnE | Spro_2156 | Spro_2159 | NAD-dependent epimerase/dehydratase; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. | Conserved hypothetical protein; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnE family. | 0.984 |
| arnA | arnF | Spro_2156 | Spro_2160 | NAD-dependent epimerase/dehydratase; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. | Conserved hypothetical protein; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnF family. | 0.966 |
| arnA | arnT | Spro_2156 | Spro_2158 | NAD-dependent epimerase/dehydratase; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. | Glycosyl transferase family 39; Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. Belongs to the glycosyltransferase 83 family. | 0.987 |
| arnB | arnA | Spro_2154 | Spro_2156 | DegT/DnrJ/EryC1/StrS aminotransferase; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. | NAD-dependent epimerase/dehydratase; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. | 0.997 |
