STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Spro_2440Transcriptional regulator, NifA subfamily, Fis Family; PFAM: sigma-54 factor interaction domain-containing protein; helix-turn-helix Fis-type; GAF domain protein; ATPase associated with various cellular activities AAA_5; SMART: AAA ATPase; KEGG: sbo:SBO_2789 formate hydrogen-lyase transcriptional activator for FdhF, hyc and hyp operons. (688 aa)    
Predicted Functional Partners:
Spro_4367
RNA polymerase, sigma 54 subunit, RpoN; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
   
 0.814
Spro_2439
TIGRFAM: hydrogenase expression/formation protein HypE; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: sec:SC2791 putative hydrogenase expression/formation protein.
  
  
 0.625
Spro_2443
KEGG: pfl:PFL_2568 sensory box transcriptional regulator, LuxR family; TIGRFAM: PAS sensor protein; PFAM: regulatory protein LuxR; PAS fold-3 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein.
   
 
 0.587
Spro_2436
TIGRFAM: hydrogenase accessory protein HypB; PFAM: cobalamin synthesis protein P47K; KEGG: stm:STM2855 hydrogenase-3 accessory protein, assembly of metallocenter.
     
 0.583
Spro_2438
TIGRFAM: hydrogenase expression/formation protein HypD; PFAM: hydrogenase formation HypD protein; KEGG: yen:YE3602 hydrogenase isoenzymes formation protein; Belongs to the HypD family.
  
    0.566
Spro_2437
TIGRFAM: hydrogenase assembly chaperone hypC/hupF; PFAM: hydrogenase expression/formation protein (HUPF/HYPC); KEGG: yen:YE2796 putative hydrogenase isoenzymes formation protein.
       0.563
Spro_4342
Multi-sensor hybrid histidine kinase; KEGG: ypi:YpsIP31758_0469 putative aerobic respiration control sensor protein ArcB; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; Hpt domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein.
   
 
 0.560
hypA
Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
       0.538
Spro_1285
Hpt sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; Hpt domain protein; SMART: extracellular solute-binding protein family 3; KEGG: pfo:Pfl_1864 Hpt sensor hybrid histidine kinase.
   
 
 0.535
Spro_1066
Histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: yen:YE1614 tetrathionate reductase complex: sensory transduction histidine kinase.
 
 
 0.525
Your Current Organism:
Serratia proteamaculans
NCBI taxonomy Id: 399741
Other names: S. proteamaculans 568, Serratia proteamaculans 568, Serratia proteamaculans str. 568, Serratia proteamaculans strain 568
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.