node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Spro_3256 | Spro_3315 | Spro_3256 | Spro_3315 | PFAM: protein of unknown function DUF1414; KEGG: ypm:YP_0880 hypothetical protein; Belongs to the UPF0352 family. | PFAM: protein of unknown function DUF412; KEGG: yen:YE1335 hypothetical protein. | 0.768 |
Spro_3256 | fadR | Spro_3256 | Spro_2748 | PFAM: protein of unknown function DUF1414; KEGG: ypm:YP_0880 hypothetical protein; Belongs to the UPF0352 family. | Fatty acid metabolism transcriptional regulator FadR; Multifunctional regulator of fatty acid metabolism. | 0.773 |
Spro_3256 | lptC | Spro_3256 | Spro_4364 | PFAM: protein of unknown function DUF1414; KEGG: ypm:YP_0880 hypothetical protein; Belongs to the UPF0352 family. | Protein of unknown function DUF1239; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family. | 0.752 |
Spro_3256 | metJ | Spro_3256 | Spro_4787 | PFAM: protein of unknown function DUF1414; KEGG: ypm:YP_0880 hypothetical protein; Belongs to the UPF0352 family. | Methionine repressor, MetJ; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | 0.735 |
Spro_3256 | mutH | Spro_3256 | Spro_3825 | PFAM: protein of unknown function DUF1414; KEGG: ypm:YP_0880 hypothetical protein; Belongs to the UPF0352 family. | DNA mismatch repair endonuclease mutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair; Belongs to the MutH family. | 0.734 |
Spro_3256 | proQ | Spro_3256 | Spro_2118 | PFAM: protein of unknown function DUF1414; KEGG: ypm:YP_0880 hypothetical protein; Belongs to the UPF0352 family. | ProQ activator of osmoprotectant transporter ProP; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. May regulate ProP activity through an RNA-based, post-transcriptional mechanism. Belongs to the ProQ family. | 0.766 |
Spro_3256 | rraB | Spro_3256 | Spro_0555 | PFAM: protein of unknown function DUF1414; KEGG: ypm:YP_0880 hypothetical protein; Belongs to the UPF0352 family. | Protein of unknown function DUF1260; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. | 0.764 |
Spro_3256 | seqA | Spro_3256 | Spro_1240 | PFAM: protein of unknown function DUF1414; KEGG: ypm:YP_0880 hypothetical protein; Belongs to the UPF0352 family. | SeqA family protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.774 |
Spro_3256 | syd | Spro_3256 | Spro_3799 | PFAM: protein of unknown function DUF1414; KEGG: ypm:YP_0880 hypothetical protein; Belongs to the UPF0352 family. | Syd family protein; Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function. Belongs to the Syd family. | 0.722 |
Spro_3256 | yihI | Spro_3256 | Spro_4885 | PFAM: protein of unknown function DUF1414; KEGG: ypm:YP_0880 hypothetical protein; Belongs to the UPF0352 family. | Protein of unknown function DUF414; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. | 0.756 |
Spro_3315 | Spro_3256 | Spro_3315 | Spro_3256 | PFAM: protein of unknown function DUF412; KEGG: yen:YE1335 hypothetical protein. | PFAM: protein of unknown function DUF1414; KEGG: ypm:YP_0880 hypothetical protein; Belongs to the UPF0352 family. | 0.768 |
Spro_3315 | fadR | Spro_3315 | Spro_2748 | PFAM: protein of unknown function DUF412; KEGG: yen:YE1335 hypothetical protein. | Fatty acid metabolism transcriptional regulator FadR; Multifunctional regulator of fatty acid metabolism. | 0.719 |
Spro_3315 | lptC | Spro_3315 | Spro_4364 | PFAM: protein of unknown function DUF412; KEGG: yen:YE1335 hypothetical protein. | Protein of unknown function DUF1239; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family. | 0.747 |
Spro_3315 | metJ | Spro_3315 | Spro_4787 | PFAM: protein of unknown function DUF412; KEGG: yen:YE1335 hypothetical protein. | Methionine repressor, MetJ; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | 0.749 |
Spro_3315 | mutH | Spro_3315 | Spro_3825 | PFAM: protein of unknown function DUF412; KEGG: yen:YE1335 hypothetical protein. | DNA mismatch repair endonuclease mutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair; Belongs to the MutH family. | 0.737 |
Spro_3315 | proQ | Spro_3315 | Spro_2118 | PFAM: protein of unknown function DUF412; KEGG: yen:YE1335 hypothetical protein. | ProQ activator of osmoprotectant transporter ProP; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. May regulate ProP activity through an RNA-based, post-transcriptional mechanism. Belongs to the ProQ family. | 0.755 |
Spro_3315 | rraB | Spro_3315 | Spro_0555 | PFAM: protein of unknown function DUF412; KEGG: yen:YE1335 hypothetical protein. | Protein of unknown function DUF1260; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. | 0.739 |
Spro_3315 | seqA | Spro_3315 | Spro_1240 | PFAM: protein of unknown function DUF412; KEGG: yen:YE1335 hypothetical protein. | SeqA family protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.752 |
Spro_3315 | syd | Spro_3315 | Spro_3799 | PFAM: protein of unknown function DUF412; KEGG: yen:YE1335 hypothetical protein. | Syd family protein; Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function. Belongs to the Syd family. | 0.755 |
Spro_3315 | yihI | Spro_3315 | Spro_4885 | PFAM: protein of unknown function DUF412; KEGG: yen:YE1335 hypothetical protein. | Protein of unknown function DUF414; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. | 0.783 |