Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
aaeAEfflux transporter, RND family, MFP subunit; Forms an efflux pump with AaeB; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (311 aa)    
Predicted Functional Partners:
aaeB
Fusaric acid resistance protein conserved region; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell; Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family.
 
  
 0.945
aaeX
PFAM: protein of unknown function DUF1656; KEGG: stm:STM3366 putative inner membrane protein.
 
  
 0.905
Spro_3742
TIGRFAM: RND efflux system, outer membrane lipoprotein, NodT family; PFAM: outer membrane efflux protein; KEGG: yen:YE3241 probable outer membrane efflux protein.
 
 
 0.656
Spro_2477
TIGRFAM: RND efflux system, outer membrane lipoprotein, NodT family; PFAM: outer membrane efflux protein; KEGG: yen:YE0445 probable outer membrane efflux lipoprotein.
 
 
 0.642
macB
ABC transporter-related protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
  
 0.632
macB-2
ABC transporter-related protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
  
 0.632
Spro_3744
TIGRFAM: drug resistance transporter, EmrB/QacA subfamily; PFAM: major facilitator superfamily MFS_1; KEGG: ypi:YpsIP31758_3202 multidrug resistance protein B.
  
 
 0.584
kefF
NAD(P)H dehydrogenase (quinone); Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefC. Shows redox enzymatic activity, but this enzymatic activity is not required for activation of KefC; Belongs to the NAD(P)H dehydrogenase (quinone) family. KefF subfamily.
   
  
 0.573
Spro_2317
ABC transporter-related protein; PFAM: ABC transporter transmembrane region; ABC transporter related; peptidase C39 bacteriocin processing; SMART: AAA ATPase; KEGG: bps:BPSL3093 colicin V processing peptidase.
  
 
 0.552
Spro_1861
TIGRFAM: RND efflux system, outer membrane lipoprotein, NodT family; PFAM: outer membrane efflux protein; KEGG: ppd:Ppro_2218 RND efflux system, outer membrane lipoprotein, NodT family.
 
 
 0.546
Your Current Organism:
Serratia proteamaculans
NCBI taxonomy Id: 399741
Other names: S. proteamaculans 568, Serratia proteamaculans 568, Serratia proteamaculans str. 568, Serratia proteamaculans strain 568
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