STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ldhMalate dehydrogenase (NAD); Catalyzes the conversion of lactate to pyruvate. (341 aa)    
Predicted Functional Partners:
ABP60811.1
PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: ecp:ECP_1403 probable pyruvate-flavodoxin oxidoreductase.
  
 0.995
ABP61622.1
PFAM: phosphate acetyl/butaryl transferase; malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: stm:STM2472 paral putative transferase.
  
 0.964
ABP60447.1
PFAM: pyruvate kinase; KEGG: stm:STM1378 pyruvate kinase I (formerly F), fructose stimulated.
  
 0.956
ABP61092.1
PFAM: pyruvate kinase; KEGG: sbo:SBO_1162 pyruvate kinase II; Belongs to the pyruvate kinase family.
  
 0.956
maeA
PFAM: malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: sfv:SFV_1742 NAD-linked malate dehydrogenase; Belongs to the malic enzymes family.
  
 0.931
ABP60618.1
PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: ecj:JW1375 fermentative D-lactate dehydrogenase, NAD-dependent.
  
 0.925
ABP60127.1
PFAM: aminotransferase, class I and II; KEGG: sdy:SDY_2329 aspartate aminotransferase.
   
 0.924
ABP60424.1
Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
  
 
 0.919
ABP60629.1
PFAM: aldehyde dehydrogenase; KEGG: ecs:ECs2021 aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.
  
 0.919
lldD
FMN-dependent alpha-hydroxy acid dehydrogenase; Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
   
 
 0.917
Your Current Organism:
Enterobacter sp. 638
NCBI taxonomy Id: 399742
Other names: E. sp. 638
Server load: high (84%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.