STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nrdRTranscriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (164 aa)    
Predicted Functional Partners:
dnaB2
Replication initiation and membrane attachment protein.
  
  
 0.885
dnaI
Primosomal protein.
     
 0.802
engA
GTP-binding protein EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
     
 0.768
birA
Biotin--protein ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
     
 0.658
argR-2
Arginine repressor ArgR; Regulates arginine biosynthesis genes.
     
 0.567
argR
Arginine repressor ArgR; Regulates arginine biosynthesis genes.
     
 0.556
argR_2
Repressor protein; Regulates arginine biosynthesis genes.
     
 0.556
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
     
 0.539
covS
TCS sensor kinase CovS-like protein.
       0.517
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
     
 0.498
Your Current Organism:
Streptococcus equi
NCBI taxonomy Id: 1051072
Other names: S. equi subsp. zooepidemicus ATCC 35246, Streptococcus equi subsp. zooepidemicus ATCC 35246, Streptococcus equi subsp. zooepidemicus str. ATCC 35246, Streptococcus equi subsp. zooepidemicus strain ATCC 35246
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.