A0A1X7SSJ4 protein (Amphimedon queenslandica)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

A0A1X7SSJ4

Uncharacterized protein. (290 aa)

Predicted Functional Partners:

A0A1X7TBS7

0.880

A0A1X7VXC0

0.874

A0A1X7VK68

0.856

A0A1X7VP90

0.801

A0A1X7THW4

0.788

A0A1X7TPZ0

0.788

A0A1X7UK55

0.745

A0A1X7UQ01

0.681

A0A1X7V724

0.680

A0A1X7V7W3

0.680

Your Current Organism:

Amphimedon queenslandica

NCBI taxonomy Id: 400682
Other names: A. queenslandica, Amphimedon queenslandica Hooper & Van Soest, 2006, Reniera sp. JGI-2005

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1X7SSJ4	A0A1X7TBS7	Uncharacterized protein.	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.880
A0A1X7SSJ4	A0A1X7THW4	Uncharacterized protein.	Uncharacterized protein.	0.788
A0A1X7SSJ4	A0A1X7TPZ0	Uncharacterized protein.	Uncharacterized protein.	0.788
A0A1X7SSJ4	A0A1X7UK55	Uncharacterized protein.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.745
A0A1X7SSJ4	A0A1X7UQ01	Uncharacterized protein.	Uncharacterized protein.	0.681
A0A1X7SSJ4	A0A1X7V724	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.680
A0A1X7SSJ4	A0A1X7V7W3	Uncharacterized protein.	FAT domain-containing protein.	0.680
A0A1X7SSJ4	A0A1X7VK68	Uncharacterized protein.	Uncharacterized protein.	0.856
A0A1X7SSJ4	A0A1X7VP90	Uncharacterized protein.	Uncharacterized protein.	0.801
A0A1X7SSJ4	A0A1X7VXC0	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.874
A0A1X7TBS7	A0A1X7SSJ4	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	Uncharacterized protein.	0.880
A0A1X7TBS7	A0A1X7THW4	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	Uncharacterized protein.	0.607
A0A1X7TBS7	A0A1X7TPZ0	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	Uncharacterized protein.	0.607
A0A1X7TBS7	A0A1X7UK55	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.711
A0A1X7TBS7	A0A1X7UQ01	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	Uncharacterized protein.	0.814
A0A1X7TBS7	A0A1X7V724	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.516
A0A1X7TBS7	A0A1X7V7W3	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	FAT domain-containing protein.	0.516
A0A1X7TBS7	A0A1X7VK68	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	Uncharacterized protein.	0.968
A0A1X7TBS7	A0A1X7VP90	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	Uncharacterized protein.	0.753
A0A1X7TBS7	A0A1X7VXC0	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	DNA helicase; Belongs to the MCM family.	0.984

page 1 of 6

Network Stats

number of nodes:

3

number of edges:

2

average node degree:

1.33

avg. local clustering coefficient:

0.667

expected number of edges:

2

PPI enrichment p-value:

0.526

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006431

methionyl-tRNA aminoacylation

2 of 3

3.31

1.18

0.0077

GO:1901838

Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I

2 of 7

2.94

1.03

0.0139

GO:0036120

Cellular response to platelet-derived growth factor stimulus

2 of 8

2.88

1.03

0.0139

GO:0009303

rRNA transcription

2 of 8

2.88

1.03

0.0139

GO:0071364

Cellular response to epidermal growth factor stimulus

2 of 16

2.58

1.02

0.0139

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004825

methionine-tRNA ligase activity

2 of 3

3.31

1.44

0.0026

GO:0004165

delta(3)-delta(2)-enoyl-CoA isomerase activity

2 of 8

2.88

1.23

0.0059

GO:0000062

fatty-acyl-CoA binding

2 of 17

2.55

1.05

0.0120

GO:0016853

Isomerase activity

3 of 183

1.7

0.95

0.0120

GO:0033218

Amide binding

3 of 290

1.5

0.76

0.0265

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030992

Intraciliary transport particle B

2 of 16

2.58

1.04

0.0129

GO:0017101

aminoacyl-tRNA synthetase multienzyme complex

2 of 13

2.67

1.04

0.0129

GO:0005782

Peroxisomal matrix

2 of 20

2.48

1.03

0.0129

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:28161

Thiolase, C-terminal domain, and delta(3)-delta(2)-enoyl-CoA isomerase activity

2 of 6

3.01

1.04

0.0135

CL:19446

aminoacyl-tRNA synthetase multienzyme complex

2 of 6

3.01

1.04

0.0135

CL:1835

Intraciliary transport particle B

2 of 15

2.61

1.03

0.0135

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00450

Selenocompound metabolism

2 of 29

2.32

1.1

0.0092

map00970

Aminoacyl-tRNA biosynthesis

2 of 83

1.87

0.76

0.0350

map00071

Fatty acid degradation

2 of 86

1.85

0.76

0.0350

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-390247

Beta-oxidation of very long chain fatty acids

2 of 14

2.64

0.95

0.0188

MAP-2408522

Selenoamino acid metabolism

2 of 29

2.32

0.79

0.0363

MAP-379716

Cytosolic tRNA aminoacylation

2 of 34

2.25

0.78

0.0363

MAP-8978868

Fatty acid metabolism

3 of 247

1.57

0.71

0.0363

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030992

Intraciliary transport particle B

2 of 11

2.74

1.06

0.0118

GOCC:0017101

aminoacyl-tRNA synthetase multienzyme complex

2 of 14

2.64

1.06

0.0118

GOCC:0005782

Peroxisomal matrix

2 of 21

2.46

1.05

0.0118

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR023458

Methionine-tRNA ligase, type 1

2 of 2

3.48

1.32

0.0042

IPR014758

Methionyl-tRNA synthetase

2 of 3

3.31

1.32

0.0042

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