A0A1X7SXW7 protein (Amphimedon queenslandica)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

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gene fusions

gene co-occurrence

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co-expression

protein homology

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A0A1X7SXW7

Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (124 aa)

Predicted Functional Partners:

A0A1X7UB19

0.944

A0A1X7U4U0

0.931

A0A1X7U5K0

0.931

A0A1X7VC66

0.895

A0A1X7UX49

0.894

A0A1X7VTH8

0.881

A0A1X7U566

0.856

A0A1X7VVL0

0.854

A0A1X7UG41

0.850

A0A1X7V8E5

0.848

Your Current Organism:

Amphimedon queenslandica

NCBI taxonomy Id: 400682
Other names: A. queenslandica, Amphimedon queenslandica Hooper & Van Soest, 2006, Reniera sp. JGI-2005

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1X7SXW7	A0A1X7U4U0	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.	RPOL_N domain-containing protein.	0.931
A0A1X7SXW7	A0A1X7U566	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.	WD_REPEATS_REGION domain-containing protein.	0.856
A0A1X7SXW7	A0A1X7U5K0	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.	Uncharacterized protein.	0.931
A0A1X7SXW7	A0A1X7UB19	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.	Uncharacterized protein.	0.944
A0A1X7SXW7	A0A1X7UG41	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.	Uncharacterized protein.	0.850
A0A1X7SXW7	A0A1X7UX49	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.	Brix domain-containing protein.	0.894
A0A1X7SXW7	A0A1X7V8E5	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.	Uncharacterized protein; Belongs to the universal ribosomal protein uS8 family.	0.848
A0A1X7SXW7	A0A1X7VC66	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.	Bms1-type G domain-containing protein.	0.895
A0A1X7SXW7	A0A1X7VTH8	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.	WD_REPEATS_REGION domain-containing protein.	0.881
A0A1X7SXW7	A0A1X7VVL0	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.	Ribosomal_S17_N domain-containing protein; Belongs to the universal ribosomal protein uS17 family.	0.854
A0A1X7U4U0	A0A1X7SXW7	RPOL_N domain-containing protein.	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.	0.931
A0A1X7U4U0	A0A1X7UB19	RPOL_N domain-containing protein.	Uncharacterized protein.	0.416
A0A1X7U4U0	A0A1X7VTH8	RPOL_N domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.532
A0A1X7U566	A0A1X7SXW7	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.	0.856
A0A1X7U566	A0A1X7UB19	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.998
A0A1X7U566	A0A1X7UX49	WD_REPEATS_REGION domain-containing protein.	Brix domain-containing protein.	0.997
A0A1X7U566	A0A1X7V8E5	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein; Belongs to the universal ribosomal protein uS8 family.	0.935
A0A1X7U566	A0A1X7VC66	WD_REPEATS_REGION domain-containing protein.	Bms1-type G domain-containing protein.	0.954
A0A1X7U566	A0A1X7VTH8	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.999
A0A1X7U566	A0A1X7VVL0	WD_REPEATS_REGION domain-containing protein.	Ribosomal_S17_N domain-containing protein; Belongs to the universal ribosomal protein uS17 family.	0.939

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Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006388

tRNA splicing, via endonucleolytic cleavage and ligation

5 of 9

2.78

4.67

1.71e-09

GO:0000379

tRNA-type intron splice site recognition and cleavage

4 of 5

2.94

3.92

6.09e-08

GO:0008033

tRNA processing

6 of 117

1.74

2.66

2.21e-07

GO:0034470

ncRNA processing

7 of 326

1.36

1.8

1.07e-06

GO:0006396

RNA processing

8 of 560

1.19

1.47

1.07e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000213

tRNA-intron endonuclease activity

3 of 4

2.91

2.45

3.34e-05

GO:0004521

Endoribonuclease activity

4 of 44

1.99

2.17

3.34e-05

GO:0140101

Catalytic activity, acting on a tRNA

4 of 95

1.66

1.57

0.00029

GO:0140098

Catalytic activity, acting on RNA

5 of 251

1.33

1.27

0.00034

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000214

tRNA-intron endonuclease complex

4 of 5

2.94

4.0

4.25e-08

GO:0140513

Nuclear protein-containing complex

9 of 659

1.17

1.52

1.14e-07

GO:0005849

mRNA cleavage factor complex

2 of 15

2.16

1.11

0.0081

GO:1902494

Catalytic complex

6 of 648

1.0

0.82

0.0014

GO:0005634

Nucleus

10 of 2393

0.65

0.56

0.00022

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17980

RNA splicing, via endonucleolytic cleavage and ligation

3 of 6

2.73

2.2

9.21e-05

CL:2899

Processing of Intronless Pre-mRNAs

2 of 6

2.55

1.03

0.0135

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03015

mRNA surveillance pathway

3 of 101

1.5

0.85

0.0154

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-77595

Processing of Intronless Pre-mRNAs

3 of 16

2.31

1.88

0.00027

MAP-75067

Processing of Capped Intronless Pre-mRNA

3 of 24

2.13

1.69

0.00055

MAP-73856

RNA Polymerase II Transcription Termination

3 of 40

1.91

1.43

0.0014

MAP-8953854

Metabolism of RNA

7 of 580

1.11

1.07

0.00019

MAP-74160

Gene expression (Transcription)

6 of 591

1.04

0.86

0.0014

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000214

tRNA-intron endonuclease complex

4 of 6

2.86

3.82

8.44e-08

GOCC:0005634

Nucleus

9 of 1402

0.84

0.79

5.17e-05

GOCC:1902494

Catalytic complex

6 of 838

0.89

0.64

0.0054

GOCC:0032991

Protein-containing complex

9 of 2362

0.61

0.47

0.0031

GOCC:0043231

Intracellular membrane-bounded organelle

10 of 3101

0.54

0.42

0.0026

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0819

tRNA processing

2 of 19

2.05

0.75

0.0397

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01974

tRNA intron endonuclease, catalytic C-terminal domain

2 of 2

3.03

1.28

0.0050

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036167

tRNA intron endonuclease, catalytic domain-like superfamily

3 of 3

3.03

2.45

3.54e-05

IPR011856

tRNA endonuclease-like domain superfamily

3 of 4

2.91

2.44

3.54e-05

IPR006677

tRNA intron endonuclease, catalytic domain-like

2 of 2

3.03

1.29

0.0047

IPR006676

tRNA-splicing endonuclease

2 of 2

3.03

1.29

0.0047

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