A0A1X7U4P6 protein (Amphimedon queenslandica)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

A0A1X7U4P6

Uncharacterized protein. (243 aa)

Predicted Functional Partners:

A0A1X7UAH0

0.492

A0A1X7UBN5

0.489

A0A1X7TTB8

0.481

A0A1X7UZS3

0.475

A0A1X7SKM1

0.473

A0A1X7SDC2

0.470

A0A1X7UFP5

0.468

A0A1X7U3E0

0.466

A0A1X7UNU0

0.462

A0A1X7V6P3

0.460

Your Current Organism:

Amphimedon queenslandica

NCBI taxonomy Id: 400682
Other names: A. queenslandica, Amphimedon queenslandica Hooper & Van Soest, 2006, Reniera sp. JGI-2005

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1X7SDC2	A0A1X7U3E0	DUF4371 domain-containing protein.	DUF4371 domain-containing protein.	0.427
A0A1X7SDC2	A0A1X7U4P6	DUF4371 domain-containing protein.	Uncharacterized protein.	0.470
A0A1X7SDC2	A0A1X7UZS3	DUF4371 domain-containing protein.	Dimer_Tnp_hAT domain-containing protein.	0.405
A0A1X7SKM1	A0A1X7TTB8	Uncharacterized protein.	Uncharacterized protein.	0.444
A0A1X7SKM1	A0A1X7U4P6	Uncharacterized protein.	Uncharacterized protein.	0.473
A0A1X7TTB8	A0A1X7SKM1	Uncharacterized protein.	Uncharacterized protein.	0.444
A0A1X7TTB8	A0A1X7U4P6	Uncharacterized protein.	Uncharacterized protein.	0.481
A0A1X7TTB8	A0A1X7UAH0	Uncharacterized protein.	Exonuclease domain-containing protein.	0.492
A0A1X7U3E0	A0A1X7SDC2	DUF4371 domain-containing protein.	DUF4371 domain-containing protein.	0.427
A0A1X7U3E0	A0A1X7U4P6	DUF4371 domain-containing protein.	Uncharacterized protein.	0.466
A0A1X7U4P6	A0A1X7SDC2	Uncharacterized protein.	DUF4371 domain-containing protein.	0.470
A0A1X7U4P6	A0A1X7SKM1	Uncharacterized protein.	Uncharacterized protein.	0.473
A0A1X7U4P6	A0A1X7TTB8	Uncharacterized protein.	Uncharacterized protein.	0.481
A0A1X7U4P6	A0A1X7U3E0	Uncharacterized protein.	DUF4371 domain-containing protein.	0.466
A0A1X7U4P6	A0A1X7UAH0	Uncharacterized protein.	Exonuclease domain-containing protein.	0.492
A0A1X7U4P6	A0A1X7UBN5	Uncharacterized protein.	Uncharacterized protein.	0.489
A0A1X7U4P6	A0A1X7UFP5	Uncharacterized protein.	Uncharacterized protein.	0.468
A0A1X7U4P6	A0A1X7UNU0	Uncharacterized protein.	Dimer_Tnp_hAT domain-containing protein.	0.462
A0A1X7U4P6	A0A1X7UZS3	Uncharacterized protein.	Dimer_Tnp_hAT domain-containing protein.	0.475
A0A1X7U4P6	A0A1X7V6P3	Uncharacterized protein.	Dimer_Tnp_hAT domain-containing protein.	0.460

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.952

expected number of edges:

47

PPI enrichment p-value:

0.995

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045471

Response to ethanol

4 of 5

2.89

3.56

2.76e-07

GO:0006636

Unsaturated fatty acid biosynthetic process

4 of 7

2.75

3.46

3.61e-07

GO:0000001

Mitochondrion inheritance

4 of 13

2.48

3.09

1.30e-06

GO:0022900

Electron transport chain

4 of 62

1.8

1.76

0.00017

GO:0006366

Transcription by RNA polymerase II

4 of 94

1.62

1.43

0.00063

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004768

stearoyl-CoA 9-desaturase activity

4 of 4

2.99

3.91

6.68e-08

GO:0003899

DNA-directed 5-3 RNA polymerase activity

3 of 22

2.12

1.62

0.00073

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005665

RNA polymerase II, core complex

4 of 12

2.51

3.18

9.10e-07

GO:0030176

Integral component of endoplasmic reticulum membrane

4 of 55

1.85

1.87

0.00011

GO:0005736

RNA polymerase I complex

2 of 11

2.25

1.22

0.0052

GO:0005666

RNA polymerase III complex

2 of 16

2.09

1.07

0.0094

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11013

Fatty acid metabolism, and Very long-chain fatty acid biosynthetic process

4 of 12

2.51

2.99

2.13e-06

CL:11025

Fatty acid desaturase type 1, conserved site, and Fatty acid elongase activity

3 of 6

2.69

2.52

2.20e-05

CL:4140

RNA polymerase, and Transcription elongation factor complex

4 of 63

1.79

1.81

0.00012

CL:4155

RNA polymerase II, core complex

2 of 7

2.44

1.27

0.0045

CL:4217

RNA polymerase III complex

2 of 14

2.14

1.0

0.0132

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03020

RNA polymerase

4 of 37

2.02

2.43

9.02e-06

map01040

Biosynthesis of unsaturated fatty acids

4 of 94

1.62

1.63

0.00016

map01212

Fatty acid metabolism

4 of 152

1.41

1.26

0.00066

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-77075

RNA Pol II CTD phosphorylation and interaction with CE

4 of 31

2.1

2.26

2.93e-05

MAP-113418

Formation of the Early Elongation Complex

4 of 31

2.1

2.26

2.93e-05

MAP-72086

mRNA Capping

4 of 33

2.07

2.25

2.93e-05

MAP-9018519

Estrogen-dependent gene expression

4 of 34

2.06

2.24

2.93e-05

MAP-75955

RNA Polymerase II Transcription Elongation

4 of 41

1.98

2.19

2.93e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005736

RNA polymerase I complex

2 of 8

2.39

0.82

0.0317

GOCC:0005665

RNA polymerase II, core complex

2 of 7

2.44

0.82

0.0317

GOCC:0055029

Nuclear DNA-directed RNA polymerase complex

3 of 61

1.68

0.76

0.0317

GOCC:0005783

Endoplasmic reticulum

4 of 287

1.13

0.61

0.0317

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0349

Heme

6 of 116

1.7

2.6

2.05e-07

KW-0275

Fatty acid biosynthesis

3 of 10

2.47

2.51

1.84e-05

KW-0249

Electron transport

3 of 18

2.21

2.2

5.11e-05

KW-0240

DNA-directed RNA polymerase

3 of 26

2.05

2.03

8.74e-05

KW-0560

Oxidoreductase

6 of 438

1.12

1.14

7.61e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00487

Fatty acid desaturase

4 of 10

2.59

3.29

6.38e-07

PF00970

Oxidoreductase FAD-binding domain

2 of 9

2.33

0.85

0.0279

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR018506

Cytochrome b5, heme-binding site

6 of 14

2.62

5.46

2.50e-11

IPR036400

Cytochrome b5-like heme/steroid binding domain superfamily

6 of 26

2.35

4.67

2.91e-10

IPR001199

Cytochrome b5-like heme/steroid binding domain

6 of 27

2.33

4.65

2.91e-10

IPR015876

Acyl-CoA desaturase

4 of 4

2.99

4.09

3.10e-08

IPR005804

Fatty acid desaturase domain

4 of 10

2.59

3.42

3.53e-07

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01117

Cytochrome b5-like Heme/Steroid binding domain

6 of 27

2.33

4.89

7.96e-11

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