A0A1X7UXB2 protein (Amphimedon queenslandica)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

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[Homology]

Score

A0A1X7UXB2

Uncharacterized protein. (311 aa)

Predicted Functional Partners:

A0A1X7SP96

0.604

A0A1X7T6Z8

0.604

A0A1X7T8J3

0.604

A0A1X7TEA8

0.604

A0A1X7TEZ5

0.604

A0A1X7TIZ4

0.604

A0A1X7TJ49

0.604

A0A1X7TNX8

0.604

A0A1X7TPQ7

0.604

A0A1X7TXM9

0.604

Your Current Organism:

Amphimedon queenslandica

NCBI taxonomy Id: 400682
Other names: A. queenslandica, Amphimedon queenslandica Hooper & Van Soest, 2006, Reniera sp. JGI-2005

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1X7SP96	A0A1X7UXB2	G_PROTEIN_RECEP_F2_4 domain-containing protein.	Uncharacterized protein.	0.604
A0A1X7T6Z8	A0A1X7UXB2	G_PROTEIN_RECEP_F2_4 domain-containing protein.	Uncharacterized protein.	0.604
A0A1X7T8J3	A0A1X7TPQ7	Uncharacterized protein.	G_PROTEIN_RECEP_F2_4 domain-containing protein.	0.451
A0A1X7T8J3	A0A1X7UXB2	Uncharacterized protein.	Uncharacterized protein.	0.604
A0A1X7TEA8	A0A1X7UXB2	Uncharacterized protein.	Uncharacterized protein.	0.604
A0A1X7TEZ5	A0A1X7UXB2	Uncharacterized protein.	Uncharacterized protein.	0.604
A0A1X7TIZ4	A0A1X7UXB2	Uncharacterized protein.	Uncharacterized protein.	0.604
A0A1X7TJ49	A0A1X7UXB2	GPS domain-containing protein.	Uncharacterized protein.	0.604
A0A1X7TNX8	A0A1X7UXB2	Uncharacterized protein.	Uncharacterized protein.	0.604
A0A1X7TPQ7	A0A1X7T8J3	G_PROTEIN_RECEP_F2_4 domain-containing protein.	Uncharacterized protein.	0.451
A0A1X7TPQ7	A0A1X7UXB2	G_PROTEIN_RECEP_F2_4 domain-containing protein.	Uncharacterized protein.	0.604
A0A1X7TXM9	A0A1X7UXB2	G_PROTEIN_RECEP_F2_4 domain-containing protein.	Uncharacterized protein.	0.604
A0A1X7UXB2	A0A1X7SP96	Uncharacterized protein.	G_PROTEIN_RECEP_F2_4 domain-containing protein.	0.604
A0A1X7UXB2	A0A1X7T6Z8	Uncharacterized protein.	G_PROTEIN_RECEP_F2_4 domain-containing protein.	0.604
A0A1X7UXB2	A0A1X7T8J3	Uncharacterized protein.	Uncharacterized protein.	0.604
A0A1X7UXB2	A0A1X7TEA8	Uncharacterized protein.	Uncharacterized protein.	0.604
A0A1X7UXB2	A0A1X7TEZ5	Uncharacterized protein.	Uncharacterized protein.	0.604
A0A1X7UXB2	A0A1X7TIZ4	Uncharacterized protein.	Uncharacterized protein.	0.604
A0A1X7UXB2	A0A1X7TJ49	Uncharacterized protein.	GPS domain-containing protein.	0.604
A0A1X7UXB2	A0A1X7TNX8	Uncharacterized protein.	Uncharacterized protein.	0.604

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.896

expected number of edges:

14

PPI enrichment p-value:

0.0178

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0060271

Cilium assembly

10 of 282

1.91

5.12

3.08e-15

GO:1905515

Non-motile cilium assembly

5 of 44

2.42

4.06

1.02e-08

GO:0007224

Smoothened signaling pathway

5 of 60

2.28

3.67

3.90e-08

GO:1904491

Protein localization to ciliary transition zone

3 of 6

3.06

3.0

3.47e-06

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0036038

MKS complex

10 of 11

3.32

14.87

1.59e-28

GO:0060170

Ciliary membrane

4 of 50

2.27

2.98

1.26e-06

GO:0036064

Ciliary basal body

3 of 134

1.71

1.19

0.0035

GO:0005813

Centrosome

4 of 433

1.33

1.0

0.0035

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:23870701

(2013) Joubert syndrome: congenital cerebellar ataxia with the molar tooth.

6 of 25

2.74

5.34

7.18e-11

PMID:26673778

(2016) Large-scale targeted sequencing comparison highlights extreme genetic heterogeneity in nephronophthisis-related ciliopathies.

6 of 28

2.69

5.31

7.18e-11

PMID:25729630

(2014) Unraveling the genetics of Joubert and Meckel-Gruber syndromes.

6 of 30

2.66

5.28

7.18e-11

PMID:28401750

(2017) The Ciliary Transition Zone: Finding the Pieces and Assembling the Gate.

6 of 35

2.6

5.14

1.09e-10

PMID:23352055

(2012) The transition zone: an essential functional compartment of cilia.

6 of 37

2.57

5.1

1.19e-10

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15866

Mixed, incl. Intraciliary transport particle, and Ciliary transition zone

11 of 76

2.52

10.72

2.14e-24

CL:15875

Mixed, incl. MKS complex, and Pronephros formation

8 of 20

2.97

9.88

1.29e-19

CL:15878

MKS complex, and Protein localization to ciliary transition zone

6 of 14

3.0

7.26

2.60e-14

CL:15880

MKS complex, and Predicted membrane protein

5 of 8

3.16

6.24

3.33e-12

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

DRE-5620912

Anchoring of the basal body to the plasma membrane

4 of 83

2.05

2.07

6.69e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0036038

MKS complex

11 of 14

3.26

16.39

9.85e-32

GOCC:0060170

Ciliary membrane

3 of 42

2.22

1.93

0.00019

GOCC:0036064

Ciliary basal body

2 of 53

1.94

0.74

0.0394

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0970

Cilium biogenesis/degradation

6 of 55

2.4

5.18

2.81e-11

KW-0969

Cilium

4 of 64

2.16

2.81

2.10e-06

KW-0966

Cell projection

5 of 160

1.86

2.63

1.01e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07162

Ciliary basal body-associated, B9 protein

3 of 3

3.36

3.07

2.90e-06

PF14995

Transmembrane protein

2 of 2

3.36

1.62

0.0012

PF09799

Predicted membrane protein

2 of 3

3.19

1.58

0.0014

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR010796

B9-type C2 domain

3 of 3

3.36

2.87

6.69e-06

IPR029248

Transmembrane protein 107

2 of 2

3.36

1.42

0.0028

IPR019184

Uncharacterised protein family, transmembrane-17

2 of 3

3.19

1.39

0.0031

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