STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0A1X7V7G5Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (453 aa)    
Predicted Functional Partners:
A0A1X7TY60
Transket_pyr domain-containing protein.
  
 
 0.996
A0A1X7V0U2
Citrate synthase; Belongs to the citrate synthase family.
  
 0.995
A0A1X7V8F0
Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.
  
 0.995
A0A1X7VVE4
Aconitate hydratase; Belongs to the aconitase/IPM isomerase family.
  
 0.992
A0A1X7VD09
Isocitrate dehydrogenase [NAD] subunit, mitochondrial.
  
 0.990
A0A1X7VMG4
Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 0.986
A0A1X7TNH2
Iso_dh domain-containing protein.
  
 0.961
A0A1X7TRJ9
Uncharacterized protein.
  
 0.961
A0A1X7VEJ3
Transket_pyr domain-containing protein.
  
 
 0.959
A0A1X7VK42
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.
  
  
 0.931
Your Current Organism:
Amphimedon queenslandica
NCBI taxonomy Id: 400682
Other names: A. queenslandica, Amphimedon queenslandica Hooper & Van Soest, 2006, Reniera sp. JGI-2005
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.