A0A1X7VRZ4 protein (Amphimedon queenslandica)

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second shell of interactors

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Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

A0A1X7VRZ4

Uncharacterized protein. (217 aa)

Predicted Functional Partners:

A0A1X7UMP1

0.615

A0A1X7V6Y7

0.615

A0A1X7U8S2

0.517

A0A1X7SY13

0.503

A0A1X7SGP9

0.469

A0A1X7SKH5

0.469

A0A1X7SKP5

0.469

A0A1X7SVQ2

0.469

A0A1X7UEV1

0.469

A0A1X7UFM8

0.469

Your Current Organism:

Amphimedon queenslandica

NCBI taxonomy Id: 400682
Other names: A. queenslandica, Amphimedon queenslandica Hooper & Van Soest, 2006, Reniera sp. JGI-2005

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1X7SGP9	A0A1X7VRZ4	Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family.	Uncharacterized protein.	0.469
A0A1X7SKH5	A0A1X7VRZ4	Uncharacterized protein.	Uncharacterized protein.	0.469
A0A1X7SKP5	A0A1X7VRZ4	Uncharacterized protein; Belongs to the peptidase C2 family.	Uncharacterized protein.	0.469
A0A1X7SVQ2	A0A1X7VRZ4	Uncharacterized protein.	Uncharacterized protein.	0.469
A0A1X7SY13	A0A1X7V6Y7	Uncharacterized protein.	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.	0.520
A0A1X7SY13	A0A1X7VRZ4	Uncharacterized protein.	Uncharacterized protein.	0.503
A0A1X7U8S2	A0A1X7VRZ4	ETF domain-containing protein.	Uncharacterized protein.	0.517
A0A1X7UEV1	A0A1X7VRZ4	Uncharacterized protein; Belongs to the peptidase C2 family.	Uncharacterized protein.	0.469
A0A1X7UFM8	A0A1X7VRZ4	Uncharacterized protein.	Uncharacterized protein.	0.469
A0A1X7UMP1	A0A1X7V6Y7	Uncharacterized protein.	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.	0.636
A0A1X7UMP1	A0A1X7VRZ4	Uncharacterized protein.	Uncharacterized protein.	0.615
A0A1X7V6Y7	A0A1X7SY13	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.	Uncharacterized protein.	0.520
A0A1X7V6Y7	A0A1X7UMP1	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.	Uncharacterized protein.	0.636
A0A1X7V6Y7	A0A1X7VRZ4	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.	Uncharacterized protein.	0.615
A0A1X7VRZ4	A0A1X7SGP9	Uncharacterized protein.	Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family.	0.469
A0A1X7VRZ4	A0A1X7SKH5	Uncharacterized protein.	Uncharacterized protein.	0.469
A0A1X7VRZ4	A0A1X7SKP5	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C2 family.	0.469
A0A1X7VRZ4	A0A1X7SVQ2	Uncharacterized protein.	Uncharacterized protein.	0.469
A0A1X7VRZ4	A0A1X7SY13	Uncharacterized protein.	Uncharacterized protein.	0.503
A0A1X7VRZ4	A0A1X7U8S2	Uncharacterized protein.	ETF domain-containing protein.	0.517

page 1 of 2

Network Stats

number of nodes:

4

number of edges:

3

average node degree:

1.5

avg. local clustering coefficient:

0.75

expected number of edges:

3

PPI enrichment p-value:

0.562

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1903778

Protein localization to vacuolar membrane

2 of 3

3.29

1.64

0.0011

GO:0010994

Free ubiquitin chain polymerization

2 of 4

3.16

1.64

0.0011

GO:0008283

Cell population proliferation

2 of 4

3.16

1.64

0.0011

GO:0070534

Protein K63-linked ubiquitination

2 of 6

2.99

1.63

0.0011

GO:2001234

Negative regulation of apoptotic signaling pathway

2 of 8

2.86

1.61

0.0012

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0061631

Ubiquitin conjugating enzyme activity

4 of 24

2.68

3.52

2.61e-07

GO:0004842

Ubiquitin-protein transferase activity

5 of 177

1.91

2.64

1.43e-06

GO:0004869

Cysteine-type endopeptidase inhibitor activity

2 of 4

3.16

1.81

0.00054

GO:0140096

Catalytic activity, acting on a protein

6 of 1625

1.03

0.83

0.0018

GO:0016740

Transferase activity

6 of 1899

0.96

0.74

0.0031

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031371

Ubiquitin conjugating enzyme complex

2 of 5

3.06

1.53

0.0017

GO:0005819

Spindle

3 of 73

2.08

1.44

0.0017

GO:0000922

Spindle pole

2 of 14

2.62

1.34

0.0035

GO:0030496

Midbody

2 of 26

2.35

1.13

0.0083

GO:0005802

trans-Golgi network

2 of 28

2.32

1.12

0.0083

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3111

IRAK2 mediated activation of TAK1 complex, and Ubiquitin conjugating enzyme activity

4 of 14

2.92

3.87

7.40e-08

CL:3091

Mixed, incl. Ubiquitin conjugating enzyme activity, and Formation of Incision Complex in GG-NER

5 of 77

2.28

3.54

7.40e-08

CL:3127

Protein localization to vacuolar membrane, and Ubiquitin conserved site

2 of 5

3.06

1.76

0.00065

CL:3113

IRAK2 mediated activation of TAK1 complex, and Cell population proliferation

2 of 5

3.06

1.76

0.00065

CL:629

Small GTPase mediated signal transduction, and Pleckstrin homology domain

2 of 43

2.13

0.85

0.0259

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04120

Ubiquitin mediated proteolysis

6 of 262

1.82

3.1

2.22e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9646399

Aggrephagy

2 of 24

2.38

0.81

0.0334

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031372

UBC13-MMS2 complex

2 of 3

3.29

1.64

0.0011

GOCC:0030496

Midbody

2 of 6

2.99

1.55

0.0016

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000608

Ubiquitin-conjugating enzyme E2

3 of 24

2.56

1.91

0.00030

IPR016135

Ubiquitin-conjugating enzyme/RWD-like

3 of 31

2.45

1.88

0.00031

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00212

Ubiquitin-conjugating enzyme E2, catalytic domain homologues

3 of 24

2.56

2.42

3.10e-05

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