C0Q70_17328 protein (Pomacea canaliculata) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

C0Q70_17328

F-box domain-containing protein. (456 aa)

Predicted Functional Partners:

C0Q70_04472

0.834

C0Q70_02871

0.757

C0Q70_21732

0.619

C0Q70_19583

0.581

C0Q70_07593

0.550

C0Q70_20262

0.547

C0Q70_08996

0.525

C0Q70_16691

0.515

C0Q70_19057

0.510

C0Q70_09019

0.455

Your Current Organism:

Pomacea canaliculata

NCBI taxonomy Id: 400727
Other names: P. canaliculata

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C0Q70_02871	C0Q70_04472	A0A2T7PR47	A0A2T7PIH0	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Uncharacterized protein; Belongs to the SKP1 family.	0.999
C0Q70_02871	C0Q70_07593	A0A2T7PR47	A0A2T7PFH2	CULLIN_2 domain-containing protein; Belongs to the cullin family.	TIP120 domain-containing protein.	0.997
C0Q70_02871	C0Q70_08996	A0A2T7PR47	A0A2T7P8J9	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	0.698
C0Q70_02871	C0Q70_16691	A0A2T7PR47	A0A2T7NQJ3	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	0.863
C0Q70_02871	C0Q70_17328	A0A2T7PR47	A0A2T7NK27	CULLIN_2 domain-containing protein; Belongs to the cullin family.	F-box domain-containing protein.	0.757
C0Q70_02871	C0Q70_19057	A0A2T7PR47	A0A2T7NIA0	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.727
C0Q70_02871	C0Q70_19583	A0A2T7PR47	A0A2T7NJR0	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Ubiquitin-like domain-containing protein.	0.991
C0Q70_02871	C0Q70_20262	A0A2T7PR47	A0A2T7NF33	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Uncharacterized protein.	0.843
C0Q70_02871	C0Q70_21732	A0A2T7PR47	A0A2T7NDC2	CULLIN_2 domain-containing protein; Belongs to the cullin family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.757
C0Q70_04472	C0Q70_02871	A0A2T7PIH0	A0A2T7PR47	Uncharacterized protein; Belongs to the SKP1 family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.999
C0Q70_04472	C0Q70_07593	A0A2T7PIH0	A0A2T7PFH2	Uncharacterized protein; Belongs to the SKP1 family.	TIP120 domain-containing protein.	0.850
C0Q70_04472	C0Q70_08996	A0A2T7PIH0	A0A2T7P8J9	Uncharacterized protein; Belongs to the SKP1 family.	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	0.936
C0Q70_04472	C0Q70_09019	A0A2T7PIH0	A0A2T7P8L7	Uncharacterized protein; Belongs to the SKP1 family.	Cullin domain-containing protein; Belongs to the cullin family.	0.920
C0Q70_04472	C0Q70_16691	A0A2T7PIH0	A0A2T7NQJ3	Uncharacterized protein; Belongs to the SKP1 family.	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	0.857
C0Q70_04472	C0Q70_17328	A0A2T7PIH0	A0A2T7NK27	Uncharacterized protein; Belongs to the SKP1 family.	F-box domain-containing protein.	0.834
C0Q70_04472	C0Q70_19057	A0A2T7PIH0	A0A2T7NIA0	Uncharacterized protein; Belongs to the SKP1 family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.737
C0Q70_04472	C0Q70_19583	A0A2T7PIH0	A0A2T7NJR0	Uncharacterized protein; Belongs to the SKP1 family.	Ubiquitin-like domain-containing protein.	0.962
C0Q70_04472	C0Q70_20262	A0A2T7PIH0	A0A2T7NF33	Uncharacterized protein; Belongs to the SKP1 family.	Uncharacterized protein.	0.974
C0Q70_04472	C0Q70_21732	A0A2T7PIH0	A0A2T7NDC2	Uncharacterized protein; Belongs to the SKP1 family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.979
C0Q70_07593	C0Q70_02871	A0A2T7PFH2	A0A2T7PR47	TIP120 domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.997

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

26

PPI enrichment p-value:

3.38e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006366

Transcription by RNA polymerase II

10 of 85

2.23

7.43

1.30e-18

GO:0001172

Transcription, RNA-templated

4 of 9

2.81

4.1

2.31e-08

GO:0098781

ncRNA transcription

4 of 14

2.62

3.74

8.55e-08

GO:0006360

Transcription by RNA polymerase I

4 of 20

2.46

3.46

2.12e-07

GO:0006383

Transcription by RNA polymerase III

4 of 21

2.44

3.43

2.30e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

7 of 24

2.63

6.87

2.51e-14

GO:0031369

Translation initiation factor binding

2 of 9

2.51

1.41

0.0026

GO:0003677

DNA binding

8 of 860

1.13

1.33

2.30e-06

GO:0003676

Nucleic acid binding

9 of 1578

0.92

0.94

7.20e-06

GO:1901363

Heterocyclic compound binding

10 of 3180

0.66

0.57

0.00014

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005665

RNA polymerase II, core complex

10 of 12

3.08

13.41

1.95e-26

GO:0005736

RNA polymerase I complex

4 of 12

2.68

4.21

1.11e-08

GO:0005666

RNA polymerase III complex

4 of 18

2.51

3.83

4.20e-08

GO:0005730

Nucleolus

5 of 273

1.42

1.64

2.40e-05

GO:0000932

P-body

2 of 30

1.98

1.14

0.0065

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7704

RNA polymerase II, core complex

9 of 10

3.12

11.75

5.86e-23

CL:7706

RNA polymerase II, core complex

5 of 5

3.16

6.39

1.79e-12

CL:7670

Mixed, incl. RNA Polymerase II Pre-transcription Events, and RNA Polymerase III Transcription

11 of 178

1.95

6.21

1.71e-19

CL:7673

Mixed, incl. RNA Polymerase II Pre-transcription Events, and Tyrosinase activity

10 of 143

2.01

6.13

8.72e-18

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03020

RNA polymerase

10 of 40

2.56

10.33

5.92e-23

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9018519

Estrogen-dependent gene expression

10 of 32

2.66

10.71

5.20e-23

MAP-77075

RNA Pol II CTD phosphorylation and interaction with CE

10 of 35

2.62

10.56

5.64e-23

MAP-72086

mRNA Capping

10 of 37

2.59

10.45

6.10e-23

MAP-113418

Formation of the Early Elongation Complex

10 of 39

2.57

10.34

7.26e-23

MAP-8939211

ESR-mediated signaling

10 of 43

2.53

10.06

1.38e-22

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

8 of 81

2.16

5.58

1.06e-13

GOCC:0005665

RNA polymerase II, core complex

4 of 4

3.16

4.76

2.03e-09

GOCC:0055029

Nuclear DNA-directed RNA polymerase complex

5 of 59

2.09

3.37

6.38e-08

GOCC:0005736

RNA polymerase I complex

2 of 5

2.76

1.68

0.00086

GOCC:0031981

Nuclear lumen

5 of 561

1.11

0.9

0.0018

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036603

RNA polymerase, RBP11-like subunit

2 of 4

2.86

0.96

0.0186

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