C0Q70_05234 protein (Pomacea canaliculata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

C0Q70_05234

Uncharacterized protein. (280 aa)

Predicted Functional Partners:

C0Q70_01711

0.763

C0Q70_07724

0.608

C0Q70_05492

0.563

C0Q70_06513

0.533

C0Q70_16253

0.516

C0Q70_10938

0.516

C0Q70_20033

0.504

C0Q70_00738

0.485

C0Q70_04873

0.454

C0Q70_19529

0.440

Your Current Organism:

Pomacea canaliculata

NCBI taxonomy Id: 400727
Other names: P. canaliculata

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C0Q70_00738	C0Q70_05234	A0A2T7PXL5	A0A2T7PKP7	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.485
C0Q70_01711	C0Q70_05234	A0A2T7Q084	A0A2T7PKP7	Uncharacterized protein.	Uncharacterized protein.	0.763
C0Q70_01711	C0Q70_06513	A0A2T7Q084	A0A2T7PP83	Uncharacterized protein.	Uncharacterized protein.	0.438
C0Q70_01711	C0Q70_07724	A0A2T7Q084	A0A2T7PFW2	Uncharacterized protein.	Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...]	0.612
C0Q70_01711	C0Q70_19529	A0A2T7Q084	A0A2T7NJM4	Uncharacterized protein.	Uncharacterized protein.	0.436
C0Q70_01711	C0Q70_20033	A0A2T7Q084	A0A2T7NED7	Uncharacterized protein.	RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.	0.487
C0Q70_04873	C0Q70_05234	A0A2T7PJK8	A0A2T7PKP7	Uncharacterized protein.	Uncharacterized protein.	0.454
C0Q70_05234	C0Q70_00738	A0A2T7PKP7	A0A2T7PXL5	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.485
C0Q70_05234	C0Q70_01711	A0A2T7PKP7	A0A2T7Q084	Uncharacterized protein.	Uncharacterized protein.	0.763
C0Q70_05234	C0Q70_04873	A0A2T7PKP7	A0A2T7PJK8	Uncharacterized protein.	Uncharacterized protein.	0.454
C0Q70_05234	C0Q70_05492	A0A2T7PKP7	A0A2T7PLC2	Uncharacterized protein.	Uncharacterized protein.	0.563
C0Q70_05234	C0Q70_06513	A0A2T7PKP7	A0A2T7PP83	Uncharacterized protein.	Uncharacterized protein.	0.533
C0Q70_05234	C0Q70_07724	A0A2T7PKP7	A0A2T7PFW2	Uncharacterized protein.	Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...]	0.608
C0Q70_05234	C0Q70_10938	A0A2T7PKP7	A0A2T7P4L8	Uncharacterized protein.	Uncharacterized protein.	0.516
C0Q70_05234	C0Q70_16253	A0A2T7PKP7	A0A2T7NPB8	Uncharacterized protein.	Uncharacterized protein.	0.516
C0Q70_05234	C0Q70_19529	A0A2T7PKP7	A0A2T7NJM4	Uncharacterized protein.	Uncharacterized protein.	0.440
C0Q70_05234	C0Q70_20033	A0A2T7PKP7	A0A2T7NED7	Uncharacterized protein.	RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.	0.504
C0Q70_05492	C0Q70_05234	A0A2T7PLC2	A0A2T7PKP7	Uncharacterized protein.	Uncharacterized protein.	0.563
C0Q70_06513	C0Q70_01711	A0A2T7PP83	A0A2T7Q084	Uncharacterized protein.	Uncharacterized protein.	0.438
C0Q70_06513	C0Q70_05234	A0A2T7PP83	A0A2T7PKP7	Uncharacterized protein.	Uncharacterized protein.	0.533

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.855

expected number of edges:

13

PPI enrichment p-value:

2.76e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:2000272

Negative regulation of signaling receptor activity

3 of 4

3.06

2.55

2.32e-05

GO:0050730

Regulation of peptidyl-tyrosine phosphorylation

3 of 5

2.96

2.54

2.32e-05

GO:0007166

Cell surface receptor signaling pathway

5 of 147

1.72

1.98

2.64e-05

GO:0006469

Negative regulation of protein kinase activity

3 of 19

2.38

1.97

0.00020

GO:0048585

Negative regulation of response to stimulus

4 of 87

1.85

1.76

0.00020

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016755

Aminoacyltransferase activity

3 of 7

2.82

2.42

3.67e-05

GO:0017124

SH3 domain binding

3 of 9

2.71

2.41

3.67e-05

GO:0001784

Phosphotyrosine residue binding

3 of 11

2.62

2.39

3.67e-05

GO:0005102

Signaling receptor binding

4 of 59

2.02

2.17

3.67e-05

GO:0019901

Protein kinase binding

3 of 76

1.78

1.25

0.0029

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045121

Membrane raft

3 of 11

2.62

2.29

5.72e-05

GO:0071944

Cell periphery

5 of 929

0.92

0.49

0.0458

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:662

Mixed, incl. Regulation of cell migration, and Protein tyrosine kinase activity

6 of 61

2.18

4.03

2.71e-09

CL:685

Phosphotyrosine residue binding, and Transmembrane receptor protein kinase activity

3 of 20

2.36

2.07

0.00012

CL:768

VHS domain, and Semaphorin interactions

2 of 5

2.79

1.61

0.0012

CL:688

Mixed, incl. Phosphotyrosine residue binding, and Basal plasma membrane

2 of 13

2.37

1.22

0.0055

CL:1687

Mixed, incl. Protein tyrosine phosphatase, catalytic domain, and EGF-like domain

2 of 28

2.04

0.89

0.0212

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04144

Endocytosis

4 of 223

1.44

1.2

0.0013

map04120

Ubiquitin mediated proteolysis

3 of 173

1.42

0.87

0.0114

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045121

Membrane raft

3 of 8

2.76

2.47

2.94e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02761

CBL proto-oncogene N-terminus, EF hand-like domain

3 of 14

2.52

2.0

0.00019

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR024159

Adaptor protein Cbl, PTB domain

3 of 7

2.82

2.21

8.99e-05

IPR014741

Adaptor protein Cbl, EF hand-like

3 of 15

2.49

1.89

0.00030

IPR000980

SH2 domain

3 of 84

1.74

0.81

0.0257

IPR036860

SH2 domain superfamily

3 of 94

1.69

0.79

0.0268

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00252

Src homology 2 domains

3 of 93

1.69

0.96

0.0114

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (18%) [HD]

Permalink

Credits

Access

Info

About

STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.

Network

Fusion

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Neighborhood

© STRING Consortium 2024

Credits

Access

Info

About