| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cbs | glyA1 | RR49_01213 | RR49_00159 | Putative cystathionine beta-synthase. | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.932 |
| cbs | hom | RR49_01213 | RR49_00680 | Putative cystathionine beta-synthase. | Homoserine dehydrogenase. | 0.911 |
| cbs | mdeA_1 | RR49_01213 | RR49_02420 | Putative cystathionine beta-synthase. | Methionine gamma-lyase. | 0.987 |
| cbs | mdeA_2 | RR49_01213 | RR49_02737 | Putative cystathionine beta-synthase. | Methionine gamma-lyase. | 0.793 |
| cbs | mdeA_3 | RR49_01213 | RR49_02964 | Putative cystathionine beta-synthase. | Methionine gamma-lyase. | 0.793 |
| cbs | metB | RR49_01213 | RR49_01214 | Putative cystathionine beta-synthase. | Cystathionine gamma-synthase. | 0.998 |
| cbs | metX | RR49_01213 | RR49_02418 | Putative cystathionine beta-synthase. | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. | 0.909 |
| cbs | metZ | RR49_01213 | RR49_02573 | Putative cystathionine beta-synthase. | O-succinylhomoserine sulfhydrylase. | 0.913 |
| cbs | serB | RR49_01213 | RR49_02268 | Putative cystathionine beta-synthase. | Phosphoserine phosphatase. | 0.925 |
| cbs | tdcB_1 | RR49_01213 | RR49_02805 | Putative cystathionine beta-synthase. | L-threonine dehydratase catabolic TdcB. | 0.816 |
| glyA1 | cbs | RR49_00159 | RR49_01213 | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative cystathionine beta-synthase. | 0.932 |
| glyA1 | hom | RR49_00159 | RR49_00680 | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Homoserine dehydrogenase. | 0.552 |
| glyA1 | mdeA_1 | RR49_00159 | RR49_02420 | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Methionine gamma-lyase. | 0.400 |
| glyA1 | metB | RR49_00159 | RR49_01214 | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Cystathionine gamma-synthase. | 0.400 |
| glyA1 | metX | RR49_00159 | RR49_02418 | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. | 0.897 |
| glyA1 | serB | RR49_00159 | RR49_02268 | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoserine phosphatase. | 0.957 |
| glyA1 | tdcB_1 | RR49_00159 | RR49_02805 | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-threonine dehydratase catabolic TdcB. | 0.838 |
| hom | cbs | RR49_00680 | RR49_01213 | Homoserine dehydrogenase. | Putative cystathionine beta-synthase. | 0.911 |
| hom | glyA1 | RR49_00680 | RR49_00159 | Homoserine dehydrogenase. | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.552 |
| hom | mdeA_1 | RR49_00680 | RR49_02420 | Homoserine dehydrogenase. | Methionine gamma-lyase. | 0.921 |