glnE protein (Bifidobacterium dentium) - STRING interaction network

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glnE

Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] (1033 aa)

Predicted Functional Partners:

glnA1

0.876

glnB

0.728

fadh2

0.718

glnD

0.713

glnA2

0.712

metE

0.702

rbpA

0.697

BDP_1400

0.690

BDP_1373

0.679

priA

0.670

Your Current Organism:

Bifidobacterium dentium

NCBI taxonomy Id: 401473
Other names: B. dentium Bd1, Bifidobacterium dentium Bd1, Bifidobacterium dentium str. Bd1, Bifidobacterium dentium strain Bd1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BDP_1373	BDP_1400	BDP_1373	BDP_1400	Ribonuclease D.	Conserved hypothetical protein.	0.616
BDP_1373	glnE	BDP_1373	BDP_1087	Ribonuclease D.	Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]	0.679
BDP_1373	priA	BDP_1373	BDP_0747	Ribonuclease D.	priA Primosomal protein N'.	0.472
BDP_1373	rbpA	BDP_1373	BDP_1159	Ribonuclease D.	Conserved hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.	0.563
BDP_1400	BDP_1373	BDP_1400	BDP_1373	Conserved hypothetical protein.	Ribonuclease D.	0.616
BDP_1400	glnE	BDP_1400	BDP_1087	Conserved hypothetical protein.	Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]	0.690
BDP_1400	priA	BDP_1400	BDP_0747	Conserved hypothetical protein.	priA Primosomal protein N'.	0.628
BDP_1400	rbpA	BDP_1400	BDP_1159	Conserved hypothetical protein.	Conserved hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.	0.774
fadh2	glnE	BDP_1086	BDP_1087	5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]	0.718
fadh2	metE	BDP_1086	BDP_1085	5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.	0.956
glnA1	glnA2	BDP_1308	BDP_1564	glnA1 Glutamine synthetase.	glnA2 Glutamine synthetase.	0.923
glnA1	glnB	BDP_1308	BDP_0190	glnA1 Glutamine synthetase.	Nitrogen regulatory protein PII; Belongs to the P(II) protein family.	0.754
glnA1	glnD	BDP_1308	BDP_0191	glnA1 Glutamine synthetase.	Protein PII uridylyltransferase.	0.688
glnA1	glnE	BDP_1308	BDP_1087	glnA1 Glutamine synthetase.	Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]	0.876
glnA2	glnA1	BDP_1564	BDP_1308	glnA2 Glutamine synthetase.	glnA1 Glutamine synthetase.	0.923
glnA2	glnB	BDP_1564	BDP_0190	glnA2 Glutamine synthetase.	Nitrogen regulatory protein PII; Belongs to the P(II) protein family.	0.750
glnA2	glnD	BDP_1564	BDP_0191	glnA2 Glutamine synthetase.	Protein PII uridylyltransferase.	0.678
glnA2	glnE	BDP_1564	BDP_1087	glnA2 Glutamine synthetase.	Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]	0.712
glnB	glnA1	BDP_0190	BDP_1308	Nitrogen regulatory protein PII; Belongs to the P(II) protein family.	glnA1 Glutamine synthetase.	0.754
glnB	glnA2	BDP_0190	BDP_1564	Nitrogen regulatory protein PII; Belongs to the P(II) protein family.	glnA2 Glutamine synthetase.	0.750

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