A0A0P1BRT5 protein (Ceraceosorus bombacis) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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Score

A0A0P1BRT5

Uncharacterized protein. (915 aa)

Predicted Functional Partners:

A0A0N7L9Y9

0.600

A0A0P1BMS3

0.579

A0A0P1BPZ6

0.579

A0A0N7LAN5

0.545

A0A0P1BEX0

0.545

A0A0P1BRH0

0.545

A0A0P1BAP1

0.527

A0A0P1BJT3

0.526

A0A0P1BKP7

0.526

A0A0P1B9M6

0.525

Your Current Organism:

Ceraceosorus bombacis

NCBI taxonomy Id: 401625
Other names: ATCC 22867, C. bombacis, Dicellomyces bombacis

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A0N7L9Y9	A0A0P1BMS3	Ubiquitin carboxyl-terminal hydrolase.	AAA-type ATPase.	0.467
A0A0N7L9Y9	A0A0P1BPZ6	Ubiquitin carboxyl-terminal hydrolase.	Valosin-containing protein; Belongs to the AAA ATPase family.	0.584
A0A0N7L9Y9	A0A0P1BRT5	Ubiquitin carboxyl-terminal hydrolase.	Uncharacterized protein.	0.600
A0A0N7LAN5	A0A0P1BAP1	Zn(2)-C6 fungal-type domain-containing protein.	Clathrin mu subunit; Belongs to the adaptor complexes medium subunit family.	0.562
A0A0N7LAN5	A0A0P1BRT5	Zn(2)-C6 fungal-type domain-containing protein.	Uncharacterized protein.	0.545
A0A0P1B9M6	A0A0P1BRT5	Transporter, ABC superfamily (Breast cancer resistance protein).	Uncharacterized protein.	0.525
A0A0P1BAP1	A0A0N7LAN5	Clathrin mu subunit; Belongs to the adaptor complexes medium subunit family.	Zn(2)-C6 fungal-type domain-containing protein.	0.562
A0A0P1BAP1	A0A0P1BEX0	Clathrin mu subunit; Belongs to the adaptor complexes medium subunit family.	UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN.	0.562
A0A0P1BAP1	A0A0P1BRH0	Clathrin mu subunit; Belongs to the adaptor complexes medium subunit family.	TRANSCRIPTION FACTOR PDR1-RELATED.	0.562
A0A0P1BAP1	A0A0P1BRT5	Clathrin mu subunit; Belongs to the adaptor complexes medium subunit family.	Uncharacterized protein.	0.527
A0A0P1BEX0	A0A0P1BAP1	UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN.	Clathrin mu subunit; Belongs to the adaptor complexes medium subunit family.	0.562
A0A0P1BEX0	A0A0P1BRT5	UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN.	Uncharacterized protein.	0.545
A0A0P1BJT3	A0A0P1BKP7	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Predicted membrane protein.	0.978
A0A0P1BJT3	A0A0P1BMS3	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	AAA-type ATPase.	0.959
A0A0P1BJT3	A0A0P1BPZ6	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Valosin-containing protein; Belongs to the AAA ATPase family.	0.981
A0A0P1BJT3	A0A0P1BRT5	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Uncharacterized protein.	0.526
A0A0P1BKP7	A0A0P1BJT3	Predicted membrane protein.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.978
A0A0P1BKP7	A0A0P1BMS3	Predicted membrane protein.	AAA-type ATPase.	0.962
A0A0P1BKP7	A0A0P1BPZ6	Predicted membrane protein.	Valosin-containing protein; Belongs to the AAA ATPase family.	0.983
A0A0P1BKP7	A0A0P1BRT5	Predicted membrane protein.	Uncharacterized protein.	0.526

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

44

average node degree:

8

avg. local clustering coefficient:

0.947

expected number of edges:

12

PPI enrichment p-value:

2.31e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044205

De novo UMP biosynthetic process

4 of 8

2.73

3.3

7.37e-07

GO:0006207

De novo pyrimidine nucleobase biosynthetic process

4 of 12

2.55

3.24

7.45e-07

GO:0042128

Nitrate assimilation

2 of 7

2.48

1.36

0.0032

GO:0044281

Small molecule metabolic process

7 of 1150

0.81

0.63

0.0024

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050464

Nitrate reductase (NADPH) activity

2 of 2

3.03

1.18

0.0076

GO:0004152

Dihydroorotate dehydrogenase activity

2 of 2

3.03

1.18

0.0076

GO:0004590

orotidine-5-phosphate decarboxylase activity

2 of 3

2.85

1.17

0.0076

GO:0043546

Molybdopterin cofactor binding

2 of 5

2.63

1.16

0.0076

GO:0030151

Molybdenum ion binding

2 of 9

2.38

1.15

0.0076

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10878

De novo UMP biosynthetic process, and Purine nucleobase transmembrane transporter activity

6 of 10

2.81

6.17

1.95e-12

CL:10881

De novo UMP biosynthetic process

3 of 5

2.81

2.86

5.50e-06

CL:10002

Molybdenum ion binding, and Prosthetic group metabolic process

3 of 15

2.33

2.17

7.36e-05

CL:10004

Oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor, and Nitronate monooxygenase

2 of 6

2.55

1.37

0.0031

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

plj00240

Pyrimidine metabolism

3 of 25

2.11

1.85

0.00024

plj00910

Nitrogen metabolism

2 of 16

2.13

1.13

0.0074

plj01100

Metabolic pathways

6 of 1076

0.77

0.55

0.0075

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-500753

Pyrimidine biosynthesis

4 of 7

2.79

3.71

1.30e-07

MAP-8956320

Nucleotide biosynthesis

4 of 23

2.27

2.78

3.43e-06

MAP-15869

Metabolism of nucleotides

4 of 80

1.73

1.65

0.00024

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01180

Dihydroorotate dehydrogenase

2 of 2

3.03

1.28

0.0050

PF03404

Mo-co oxidoreductase dimerisation domain

2 of 5

2.63

1.13

0.0087

PF00174

Oxidoreductase molybdopterin binding domain

2 of 5

2.63

1.13

0.0087

PF00970

Oxidoreductase FAD-binding domain

2 of 10

2.33

1.01

0.0137

PF00175

Oxidoreductase NAD-binding domain

2 of 18

2.07

0.81

0.0314

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036400

Cytochrome b5-like heme/steroid binding domain superfamily

3 of 21

2.18

1.3

0.0036

IPR001199

Cytochrome b5-like heme/steroid binding domain

3 of 21

2.18

1.3

0.0036

IPR005720

Dihydroorotate dehydrogenase domain

2 of 2

3.03

1.29

0.0047

IPR036374

Oxidoreductase, molybdopterin-binding domain superfamily

2 of 5

2.63

1.05

0.0123

IPR008335

Eukaryotic molybdopterin oxidoreductase

2 of 5

2.63

1.05

0.0123

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01117

Cytochrome b5-like Heme/Steroid binding domain

3 of 22

2.16

1.72

0.00048

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