node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SEQ50390.1 | SER18148.1 | SAMN05216188_103253 | SAMN05216188_108229 | Glutamate synthase (NADPH/NADH) large chain. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.565 |
SEQ50390.1 | SER26543.1 | SAMN05216188_103253 | SAMN05216188_109218 | Glutamate synthase (NADPH/NADH) large chain. | 2-oxoglutarate decarboxylase. | 0.968 |
SEQ50390.1 | folD | SAMN05216188_103253 | SAMN05216188_101895 | Glutamate synthase (NADPH/NADH) large chain. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.704 |
SEQ50390.1 | gcvH | SAMN05216188_103253 | SAMN05216188_109207 | Glutamate synthase (NADPH/NADH) large chain. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.936 |
SEQ50390.1 | gcvH-2 | SAMN05216188_103253 | SAMN05216188_111103 | Glutamate synthase (NADPH/NADH) large chain. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.936 |
SEQ50390.1 | gcvP | SAMN05216188_103253 | SAMN05216188_111110 | Glutamate synthase (NADPH/NADH) large chain. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.973 |
SEQ50390.1 | gcvT | SAMN05216188_103253 | SAMN05216188_103201 | Glutamate synthase (NADPH/NADH) large chain. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.964 |
SEQ50390.1 | glyA | SAMN05216188_103253 | SAMN05216188_101371 | Glutamate synthase (NADPH/NADH) large chain. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.935 |
SEQ50390.1 | glyA-2 | SAMN05216188_103253 | SAMN05216188_103200 | Glutamate synthase (NADPH/NADH) large chain. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.935 |
SEQ50390.1 | purD | SAMN05216188_103253 | SAMN05216188_101419 | Glutamate synthase (NADPH/NADH) large chain. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.830 |
SER18148.1 | SEQ50390.1 | SAMN05216188_108229 | SAMN05216188_103253 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glutamate synthase (NADPH/NADH) large chain. | 0.565 |
SER18148.1 | SER26543.1 | SAMN05216188_108229 | SAMN05216188_109218 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 2-oxoglutarate decarboxylase. | 0.783 |
SER18148.1 | folD | SAMN05216188_108229 | SAMN05216188_101895 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.901 |
SER18148.1 | gcvH | SAMN05216188_108229 | SAMN05216188_109207 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.825 |
SER18148.1 | gcvH-2 | SAMN05216188_108229 | SAMN05216188_111103 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.825 |
SER18148.1 | gcvP | SAMN05216188_108229 | SAMN05216188_111110 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.972 |
SER18148.1 | gcvT | SAMN05216188_108229 | SAMN05216188_103201 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.919 |
SER18148.1 | glyA | SAMN05216188_108229 | SAMN05216188_101371 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.870 |
SER18148.1 | glyA-2 | SAMN05216188_108229 | SAMN05216188_103200 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.870 |
SER18148.1 | purD | SAMN05216188_108229 | SAMN05216188_101419 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.537 |