Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Rpic_0200TIGRFAM: glutamate/cysteine ligase; PFAM: glutamate--cysteine ligase GshA; KEGG: rso:RSc0344 hypothetical protein. (431 aa)    
Predicted Functional Partners:
gshB
KEGG: rso:RSc0345 glutathione synthetase; TIGRFAM: glutathione synthetase; PFAM: glutathione synthetase domain protein; glutathione synthetase ATP-binding; RimK domain protein ATP-grasp; Belongs to the prokaryotic GSH synthase family.
 
  
 0.987
secF
Protein-export membrane protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
 
 
 0.930
Rpic_3493
Glutamate--cysteine ligase GCS2; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
  
  
  0.922
Rpic_2265
TIGRFAM: aminopeptidase N; PFAM: Peptidase M1 membrane alanine aminopeptidase; KEGG: rso:RSc2125 probable aminopeptidase N (alpha-aminoacylpeptide hydrolase) metalloprotease protein.
   
 
 0.913
Rpic_4680
PFAM: Peptidase M1 membrane alanine aminopeptidase; KEGG: rso:RS00411 putative aminopeptidase transmembrane protein.
   
 
 0.912
Rpic_2374
PFAM: Allophanate hydrolase subunit 1; KEGG: rso:RSc2171 hypothetical protein.
     
 0.905
pepA
Leucyl aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.
  
 
 0.905
pxpA
LamB/YcsF family protein; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
     
  0.900
Rpic_2373
KEGG: rso:RSc2170 hypothetical protein; TIGRFAM: urea amidolyase related protein; PFAM: Allophanate hydrolase subunit 2.
     
  0.900
Rpic_2766
Gamma-glutamyltransferase; PFAM: gamma-glutamyltranspeptidase; KEGG: rso:RSc2501 putative gamma-glutamyltranspeptidase protein.
     
  0.900
Your Current Organism:
Ralstonia pickettii 12J
NCBI taxonomy Id: 402626
Other names: R. pickettii 12J, Ralstonia pickettii str. 12J, Ralstonia pickettii strain 12J
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