STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
iscSCysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (405 aa)    
Predicted Functional Partners:
Rpic_0885
FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
 
 0.999
Rpic_0756
PFAM: SirA family protein; KEGG: rso:RSc0810 hypothetical protein; Belongs to the sulfur carrier protein TusA family.
   
 0.993
Rpic_0883
TIGRFAM: transcriptional regulator, Rrf2 family; iron-sulfur cluster assembly transcription factor IscR; PFAM: protein of unknown function UPF0074; KEGG: rso:RSc1018 hypothetical protein.
  
 0.987
hscB
Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.
 
 
 0.985
Rpic_0890
TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: rso:RSc1025 probable ferredoxin [2Fe-2S] protein.
 
 0.982
Rpic_0886
TIGRFAM: iron-sulfur cluster assembly protein IscA; iron-sulfur cluster assembly accessory protein; PFAM: HesB/YadR/YfhF-family protein; KEGG: rso:RSc1021 hypothetical protein; Belongs to the HesB/IscA family.
 
  
 0.971
Rpic_0207
PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: rso:RSc0351 molybdopterin biosynthesis protein MoeB.
   
 0.956
cyaY
Iron donor protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.
  
 0.949
Rpic_2431
PFAM: Rhodanese domain protein; KEGG: rso:RSc2226 probable thiosulfate sulfurtransferase protein.
  
 0.924
Rpic_2002
PFAM: aminotransferase class V; aromatic amino acid beta-eliminating lyase/threonine aldolase; protein of unknown function DUF442; KEGG: bur:Bcep18194_B2744 hypothetical protein.
 
  
 
0.917
Your Current Organism:
Ralstonia pickettii 12J
NCBI taxonomy Id: 402626
Other names: R. pickettii 12J, Ralstonia pickettii str. 12J, Ralstonia pickettii strain 12J
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