STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SJAG_037153-hydroxy-3-methylglutaryl coenzyme A reductase. (1060 aa)    
Predicted Functional Partners:
SJAG_04499
3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
  
 
 0.995
SJAG_04865
Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
  
 0.955
SJAG_00370
Squalene monooxygenase Erg1.
   
  
 0.902
SJAG_03750
Sterol 14-demethylase; Belongs to the cytochrome P450 family.
   
 
 0.880
SJAG_00770
INSIG domain-containing protein.
   
 
 0.847
SJAG_03349
Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.
  
 
 0.842
SJAG_05274
Synviolin family ubiquitin-protein ligase Hrd1.
   
 
 0.823
SJAG_01307
Sterol regulatory element binding protein.
     
 0.760
SJAG_04018
Sre1 cleavage activating protein Scp1.
   
  
 0.752
SJAG_03018
C-4 methylsterol oxidase; Belongs to the sterol desaturase family.
   
  
 0.728
Your Current Organism:
Schizosaccharomyces japonicus
NCBI taxonomy Id: 402676
Other names: S. japonicus yFS275, Schizosaccharomyces japonicus yFS275
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