node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABO34401.1 | dadD | MmarC5_0084 | MmarC5_0086 | PFAM: S-layer protein; KEGG: mmp:MMP1493 hypothetical protein. | Amidohydrolase; Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'- methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'- deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deoxyribose m [...] | 0.464 |
ABO34401.1 | pyrE | MmarC5_0084 | MmarC5_0085 | PFAM: S-layer protein; KEGG: mmp:MMP1493 hypothetical protein. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.579 |
ABO34702.1 | ABO35558.1 | MmarC5_0386 | MmarC5_1260 | PFAM: peptidase M24; KEGG: mmp:MMP1204 metallopeptidase family M24:Xaa-Pro dipeptidase/Xaa-Pro aminopeptidase. | PFAM: amidohydrolase; KEGG: mmp:MMP0378 atrazine chlorohydrolase related protein. | 0.419 |
ABO34702.1 | dadD | MmarC5_0386 | MmarC5_0086 | PFAM: peptidase M24; KEGG: mmp:MMP1204 metallopeptidase family M24:Xaa-Pro dipeptidase/Xaa-Pro aminopeptidase. | Amidohydrolase; Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'- methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'- deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deoxyribose m [...] | 0.424 |
ABO34702.1 | fucA | MmarC5_0386 | MmarC5_0403 | PFAM: peptidase M24; KEGG: mmp:MMP1204 metallopeptidase family M24:Xaa-Pro dipeptidase/Xaa-Pro aminopeptidase. | Class II aldolase/adducin family protein; Involved in the biosynthesis of the coenzyme F420 which requires phospholactate produced via the aldol cleavage of L-fuculose 1-phosphate and the NAD(+)-dependent oxidation of (S)-lactaldehyde. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and S-lactaldehyde. | 0.400 |
ABO34702.1 | topA | MmarC5_0386 | MmarC5_0781 | PFAM: peptidase M24; KEGG: mmp:MMP1204 metallopeptidase family M24:Xaa-Pro dipeptidase/Xaa-Pro aminopeptidase. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.965 |
ABO35202.1 | ABO35558.1 | MmarC5_0895 | MmarC5_1260 | TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: mmp:MMP0681 xanthine/uracil permease family. | PFAM: amidohydrolase; KEGG: mmp:MMP0378 atrazine chlorohydrolase related protein. | 0.405 |
ABO35202.1 | dadD | MmarC5_0895 | MmarC5_0086 | TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: mmp:MMP0681 xanthine/uracil permease family. | Amidohydrolase; Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'- methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'- deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deoxyribose m [...] | 0.407 |
ABO35202.1 | pyrE | MmarC5_0895 | MmarC5_0085 | TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: mmp:MMP0681 xanthine/uracil permease family. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.944 |
ABO35202.1 | upp | MmarC5_0895 | MmarC5_0896 | TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: mmp:MMP0681 xanthine/uracil permease family. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.944 |
ABO35558.1 | ABO34702.1 | MmarC5_1260 | MmarC5_0386 | PFAM: amidohydrolase; KEGG: mmp:MMP0378 atrazine chlorohydrolase related protein. | PFAM: peptidase M24; KEGG: mmp:MMP1204 metallopeptidase family M24:Xaa-Pro dipeptidase/Xaa-Pro aminopeptidase. | 0.419 |
ABO35558.1 | ABO35202.1 | MmarC5_1260 | MmarC5_0895 | PFAM: amidohydrolase; KEGG: mmp:MMP0378 atrazine chlorohydrolase related protein. | TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: mmp:MMP0681 xanthine/uracil permease family. | 0.405 |
ABO35558.1 | ABO35788.1 | MmarC5_1260 | MmarC5_1491 | PFAM: amidohydrolase; KEGG: mmp:MMP0378 atrazine chlorohydrolase related protein. | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | 0.957 |
ABO35558.1 | dadD | MmarC5_1260 | MmarC5_0086 | PFAM: amidohydrolase; KEGG: mmp:MMP0378 atrazine chlorohydrolase related protein. | Amidohydrolase; Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'- methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'- deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deoxyribose m [...] | 0.908 |
ABO35558.1 | speE | MmarC5_1260 | MmarC5_1825 | PFAM: amidohydrolase; KEGG: mmp:MMP0378 atrazine chlorohydrolase related protein. | Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine; Belongs to the spermidine/spermine synthase family. | 0.919 |
ABO35558.1 | topA | MmarC5_1260 | MmarC5_0781 | PFAM: amidohydrolase; KEGG: mmp:MMP0378 atrazine chlorohydrolase related protein. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.459 |
ABO35558.1 | upp | MmarC5_1260 | MmarC5_0896 | PFAM: amidohydrolase; KEGG: mmp:MMP0378 atrazine chlorohydrolase related protein. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.430 |
ABO35788.1 | ABO35558.1 | MmarC5_1491 | MmarC5_1260 | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | PFAM: amidohydrolase; KEGG: mmp:MMP0378 atrazine chlorohydrolase related protein. | 0.957 |
ABO35788.1 | dadD | MmarC5_1491 | MmarC5_0086 | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Amidohydrolase; Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'- methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'- deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deoxyribose m [...] | 0.992 |
ABO35788.1 | fucA | MmarC5_1491 | MmarC5_0403 | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Class II aldolase/adducin family protein; Involved in the biosynthesis of the coenzyme F420 which requires phospholactate produced via the aldol cleavage of L-fuculose 1-phosphate and the NAD(+)-dependent oxidation of (S)-lactaldehyde. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and S-lactaldehyde. | 0.788 |