node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABO34828.1 | dcd | MmarC5_0514 | MmarC5_0152 | KEGG: mmp:MMP1075 dUTP diphosphatase. | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.900 |
ABO34828.1 | ndk | MmarC5_0514 | MmarC5_1390 | KEGG: mmp:MMP1075 dUTP diphosphatase. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | 0.933 |
ABO34828.1 | surE | MmarC5_0514 | MmarC5_0542 | KEGG: mmp:MMP1075 dUTP diphosphatase. | 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.916 |
ABO34828.1 | thyA | MmarC5_0514 | MmarC5_0199 | KEGG: mmp:MMP1075 dUTP diphosphatase. | Thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily. | 0.935 |
ABO34828.1 | tmk | MmarC5_0514 | MmarC5_0559 | KEGG: mmp:MMP1075 dUTP diphosphatase. | dTMP kinase; PFAM: thymidylate kinase; KEGG: mmp:MMP1034 thymidylate kinase. | 0.932 |
ABO34828.1 | topA | MmarC5_0514 | MmarC5_0781 | KEGG: mmp:MMP1075 dUTP diphosphatase. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.718 |
dcd | ABO34828.1 | MmarC5_0152 | MmarC5_0514 | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | KEGG: mmp:MMP1075 dUTP diphosphatase. | 0.900 |
dcd | ndk | MmarC5_0152 | MmarC5_1390 | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | 0.933 |
dcd | surE | MmarC5_0152 | MmarC5_0542 | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.916 |
dcd | thyA | MmarC5_0152 | MmarC5_0199 | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily. | 0.935 |
dcd | tmk | MmarC5_0152 | MmarC5_0559 | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | dTMP kinase; PFAM: thymidylate kinase; KEGG: mmp:MMP1034 thymidylate kinase. | 0.935 |
dcd | topA | MmarC5_0152 | MmarC5_0781 | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.718 |
ndk | ABO34828.1 | MmarC5_1390 | MmarC5_0514 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | KEGG: mmp:MMP1075 dUTP diphosphatase. | 0.933 |
ndk | dcd | MmarC5_1390 | MmarC5_0152 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.933 |
ndk | pyrH | MmarC5_1390 | MmarC5_1253 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | Uridylate kinase, putative; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.962 |
ndk | rpl11 | MmarC5_1390 | MmarC5_0145 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | LSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. | 0.929 |
ndk | tmk | MmarC5_1390 | MmarC5_0559 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | dTMP kinase; PFAM: thymidylate kinase; KEGG: mmp:MMP1034 thymidylate kinase. | 0.958 |
pyrH | ndk | MmarC5_1253 | MmarC5_1390 | Uridylate kinase, putative; Catalyzes the reversible phosphorylation of UMP to UDP. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | 0.962 |
pyrH | rpl11 | MmarC5_1253 | MmarC5_0145 | Uridylate kinase, putative; Catalyzes the reversible phosphorylation of UMP to UDP. | LSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. | 0.794 |
pyrH | surE | MmarC5_1253 | MmarC5_0542 | Uridylate kinase, putative; Catalyzes the reversible phosphorylation of UMP to UDP. | 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.953 |