STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pthpeptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. (116 aa)    
Predicted Functional Partners:
tgtA
Archaeosine tRNA-ribosyltransferase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family.
       0.952
fen
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...]
 
     0.635
rpl4
LSU ribosomal protein L4P; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
  
   
 0.615
rpl7ae
LSU ribosomal protein L7AE; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
 
    0.584
ABO34587.1
PFAM: RNA polymerase, dimerisation; RNA polymerase, insert; SMART: RNA polymerase, RpoA/D/Rpb3-type; KEGG: mmp:MMP1322 DNA-directed RNA polymerase, subunit D.
  
    0.572
carS
Protein of unknown function DUF46; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids.
 
 
   0.547
rps3ae
PFAM: ribosomal protein S3Ae; KEGG: mmp:MMP0669 SSU ribosomal protein S3AE; Belongs to the eukaryotic ribosomal protein eS1 family.
  
     0.546
eif6
Translation initiation factor 6 (aeIF-6); Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.
 
    0.540
ABO34495.1
PFAM: Protein of unknown function DUF1610; KEGG: mmp:MMP1400 hypothetical protein.
 
     0.539
rpl15e
PFAM: Ribosomal protein L15e; KEGG: mmp:MMP0298 LSU ribosomal protein L15E; Belongs to the eukaryotic ribosomal protein eL15 family.
  
     0.539
Your Current Organism:
Methanococcus maripaludis C5
NCBI taxonomy Id: 402880
Other names: M. maripaludis C5, Methanococcus maripaludis str. C5, Methanococcus maripaludis strain C5
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.