STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
htpXHeat shock protein, Metallo peptidase, MEROPS family M48B; PFAM: peptidase M48, Ste24p; KEGG: mmp:MMP0399 peptidase family M48; Belongs to the peptidase M48B family. (285 aa)    
Predicted Functional Partners:
ABO35536.1
Membrane-bound hydrogenase subunit ehbQ; PFAM: amino acid-binding ACT domain protein; KEGG: mmp:MMP0400 hypothetical protein.
  
    0.995
ABO35538.1
PFAM: GHMP kinase; KEGG: mmp:MMP0398 hypothetical protein.
  
    0.991
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
  
    0.977
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.916
ABO34806.1
PFAM: Auxin Efflux Carrier; KEGG: mmp:MMP1092 hypothetical protein.
  
  
 0.905
ABO35535.1
PFAM: Methionine synthase, vitamin-B12 independent; Cobalamin-independent synthase MetE, N-terminal domain protein; KEGG: mmp:MMP0401 methionine synthase.
  
  
 0.858
tal
Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily.
  
  
 0.839
ABO34631.1
Thiol-driven fumarate reductase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: mmp:MMP1277 fumarate reductase/succinate dehydrogenase, flavoprotein subunit.
  
  
 0.823
ABO35265.1
PFAM: Lactate/malate dehydrogenase; KEGG: mmp:MMP0645 malate dehydrogenase, MDHII (NADP+-dependent); Belongs to the LDH/MDH superfamily.
  
 
 0.810
ABO34793.1
KEGG: mmp:MMP1105 succinate-CoA ligase (ADP-forming), beta chain; TIGRFAM: succinyl-CoA synthetase, beta subunit; PFAM: ATP-citrate lyase/succinyl-CoA ligase; ATP-grasp domain protein.
  
  
 0.795
Your Current Organism:
Methanococcus maripaludis C5
NCBI taxonomy Id: 402880
Other names: M. maripaludis C5, Methanococcus maripaludis str. C5, Methanococcus maripaludis strain C5
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