Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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mscLLarge conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. (142 aa)    
Predicted Functional Partners:
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
  
  
 0.908
metK
Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
    0.832
Plav_0713
Molybdenum cofactor biosynthesis protein B; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family.
     
 0.646
Plav_1395
PFAM: protein of unknown function UPF0005; KEGG: mes:Meso_3353 protein of unknown function UPF0005; Belongs to the BI1 family.
  
  
 0.519
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
     
 0.506
Plav_0452
PFAM: MscS Mechanosensitive ion channel; KEGG: mmr:Mmar10_0527 MscS mechanosensitive ion channel.
     
 0.472
Plav_0585
Regulator of ribonuclease activity A; Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
   
  
 0.468
Plav_2917
PFAM: TrkA-N domain protein; sodium/hydrogen exchanger; KEGG: hch:HCH_06854 Kef-type K+ transport system, predicted NAD-binding component.
     
 0.466
Plav_2280
PFAM: TrkA-N domain protein; sodium/hydrogen exchanger; KEGG: sde:Sde_1457 K+ efflux antiporter, putative (KEA1); Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.
     
 0.456
Plav_2377
TIGRFAM: potassium efflux system protein; PFAM: TrkA-N domain protein; sodium/hydrogen exchanger; KEGG: mpt:Mpe_A0112 Kef-type K+ transport; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.
     
 0.456
Your Current Organism:
Parvibaculum lavamentivorans
NCBI taxonomy Id: 402881
Other names: P. lavamentivorans DS-1, Parvibaculum lavamentivorans DS-1, Parvibaculum lavamentivorans str. DS-1, Parvibaculum lavamentivorans strain DS-1
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