node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Plav_0335 | Plav_3150 | Plav_0335 | Plav_3150 | ExsB family protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: xac:XAC3614 6-pyruvoyltetrahydropterin synthase. | 0.876 |
Plav_0335 | queC | Plav_0335 | Plav_3148 | ExsB family protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.916 |
Plav_0335 | queE | Plav_0335 | Plav_3149 | ExsB family protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.969 |
Plav_0335 | queF | Plav_0335 | Plav_3151 | ExsB family protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.969 |
Plav_3150 | Plav_0335 | Plav_3150 | Plav_0335 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: xac:XAC3614 6-pyruvoyltetrahydropterin synthase. | ExsB family protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.876 |
Plav_3150 | Plav_3152 | Plav_3150 | Plav_3152 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: xac:XAC3614 6-pyruvoyltetrahydropterin synthase. | PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: mag:amb3096 signal transduction histidine kinase. | 0.572 |
Plav_3150 | guaA | Plav_3150 | Plav_1171 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: xac:XAC3614 6-pyruvoyltetrahydropterin synthase. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.525 |
Plav_3150 | queA | Plav_3150 | Plav_3053 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: xac:XAC3614 6-pyruvoyltetrahydropterin synthase. | Queuosine biosynthesis protein; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 0.409 |
Plav_3150 | queC | Plav_3150 | Plav_3148 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: xac:XAC3614 6-pyruvoyltetrahydropterin synthase. | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.984 |
Plav_3150 | queE | Plav_3150 | Plav_3149 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: xac:XAC3614 6-pyruvoyltetrahydropterin synthase. | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.999 |
Plav_3150 | queF | Plav_3150 | Plav_3151 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: xac:XAC3614 6-pyruvoyltetrahydropterin synthase. | GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.974 |
Plav_3150 | tgt | Plav_3150 | Plav_3054 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: xac:XAC3614 6-pyruvoyltetrahydropterin synthase. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] | 0.422 |
Plav_3152 | Plav_3150 | Plav_3152 | Plav_3150 | PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: mag:amb3096 signal transduction histidine kinase. | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: xac:XAC3614 6-pyruvoyltetrahydropterin synthase. | 0.572 |
Plav_3152 | queC | Plav_3152 | Plav_3148 | PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: mag:amb3096 signal transduction histidine kinase. | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.573 |
Plav_3152 | queE | Plav_3152 | Plav_3149 | PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: mag:amb3096 signal transduction histidine kinase. | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.572 |
Plav_3152 | queF | Plav_3152 | Plav_3151 | PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: mag:amb3096 signal transduction histidine kinase. | GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.577 |
guaA | Plav_3150 | Plav_1171 | Plav_3150 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: xac:XAC3614 6-pyruvoyltetrahydropterin synthase. | 0.525 |
guaA | guaB | Plav_1171 | Plav_1168 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
guaA | queE | Plav_1171 | Plav_3149 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.525 |
guaA | queF | Plav_1171 | Plav_3151 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.525 |