Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AJE38866.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the LeuD family. (140 aa)    
Predicted Functional Partners:
kgd
Alpha-ketoglutarate decarboxylase; Kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.952
AJE41195.1
Citrate synthase 2; Forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family.
 
 0.949
AJE43794.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.945
AJE40764.1
Citrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family.
 
 0.940
AJE44408.1
Citrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.911
aspA
Aspartate ammonia-lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.893
fumC
Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.893
atpA
ATP synthase F0F1 subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.
   
 0.863
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
 
 0.860
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
  
 0.844
Your Current Organism:
Streptomyces nodosus
NCBI taxonomy Id: 40318
Other names: ATCC 14899, ATCC 23942, BCRC 13768, CBS 926.68, CCRC 13768, CCRC:13768, DSM 40109, IFO 12895, ISP 5109, JCM 4297, JCM 4656, KCTC 9035, LMG 19340, LMG:19340, NBRC 12895, NCIMB 12816, NRRL B-2371, NRRL-ISP 5109, RIA 831, S. nodosus
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