lipA protein (Legionella tucsonensis) - STRING interaction network

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lipA

Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (329 aa)

Predicted Functional Partners:

lssX

0.993

gcvH

0.951

rir1

0.679

Ltuc_0672

0.653

nadE

0.566

Ltuc_0671

0.547

sucB

0.526

Ltuc_1706

0.516

trpE

0.448

Ltuc_1208

0.446

Your Current Organism:

Legionella tucsonensis

NCBI taxonomy Id: 40335
Other names: ATCC 49180, CCUG 31119, CIP 105113, DSM 19246, L. tucsonensis, NCTC 12439

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ltuc_0671	Ltuc_0672	Ltuc_0671	Ltuc_0672	CBS domain protein.	Hypothetical protein.	0.657
Ltuc_0671	lipA	Ltuc_0671	Ltuc_0673	CBS domain protein.	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	0.547
Ltuc_0672	Ltuc_0671	Ltuc_0672	Ltuc_0671	Hypothetical protein.	CBS domain protein.	0.657
Ltuc_0672	lipA	Ltuc_0672	Ltuc_0673	Hypothetical protein.	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	0.653
Ltuc_1208	lipA	Ltuc_1208	Ltuc_0673	MutT/nudix family transporter protein.	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	0.446
Ltuc_1208	nadE	Ltuc_1208	Ltuc_0599	MutT/nudix family transporter protein.	Glutamine dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.	0.734
Ltuc_1208	rir1	Ltuc_1208	Ltuc_0940	MutT/nudix family transporter protein.	Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.434
Ltuc_1706	gcvH	Ltuc_1706	Ltuc_0375	Pyruvate/2-oxoglutarate dehydrogenase subunit E1.	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	0.940
Ltuc_1706	lipA	Ltuc_1706	Ltuc_0673	Pyruvate/2-oxoglutarate dehydrogenase subunit E1.	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	0.516
Ltuc_1706	lssX	Ltuc_1706	Ltuc_1032	Pyruvate/2-oxoglutarate dehydrogenase subunit E1.	Legionella secretion system protein X; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.	0.559
Ltuc_1706	sucB	Ltuc_1706	Ltuc_2703	Pyruvate/2-oxoglutarate dehydrogenase subunit E1.	Dihydrolipoamide succinyltransferase subunit E2; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).	0.999
gcvH	Ltuc_1706	Ltuc_0375	Ltuc_1706	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Pyruvate/2-oxoglutarate dehydrogenase subunit E1.	0.940
gcvH	lipA	Ltuc_0375	Ltuc_0673	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	0.951
gcvH	lssX	Ltuc_0375	Ltuc_1032	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Legionella secretion system protein X; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.	0.949
gcvH	sucB	Ltuc_0375	Ltuc_2703	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Dihydrolipoamide succinyltransferase subunit E2; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).	0.697
lipA	Ltuc_0671	Ltuc_0673	Ltuc_0671	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	CBS domain protein.	0.547
lipA	Ltuc_0672	Ltuc_0673	Ltuc_0672	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	Hypothetical protein.	0.653
lipA	Ltuc_1208	Ltuc_0673	Ltuc_1208	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	MutT/nudix family transporter protein.	0.446
lipA	Ltuc_1706	Ltuc_0673	Ltuc_1706	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	Pyruvate/2-oxoglutarate dehydrogenase subunit E1.	0.516
lipA	gcvH	Ltuc_0673	Ltuc_0375	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	0.951

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