Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)    
Predicted Functional Partners:
gltA
Citrate synthase; Belongs to the citrate synthase family.
  
 0.981
prpC
2-methylcitrate synthase; Belongs to the citrate synthase family.
  
 0.981
fumC
Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.978
icd
Isocitrate dehydrogenase.
  
 0.977
Ltuc_0772
2-oxoglutarate ferredoxin oxidoreductase subunit alpha.
  
 
 0.968
Ltuc_0828
Ferredoxin II (4Fe-4S); Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
  
 
 0.942
sdhB
Succinate dehydrogenase iron-sulfur subunit.
  
 0.929
Ltuc_2640
Hypothetical protein.
  
 0.927
pykA
Pyruvate kinase II; Belongs to the pyruvate kinase family.
  
 0.924
Ltuc_2571
Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
     
 0.917
Your Current Organism:
Legionella tucsonensis
NCBI taxonomy Id: 40335
Other names: ATCC 49180, CCUG 31119, CIP 105113, DSM 19246, L. tucsonensis, NCTC 12439
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