STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PITG_00686Tyrosyl-DNA phosphodiesterase, putative. (1123 aa)    
Predicted Functional Partners:
PITG_02197
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
    
 
 0.946
PITG_08918
TYR_PHOSPHATASE_2 domain-containing protein.
    
 
 0.887
PITG_12104
ATP-dependent DNA helicase 2 subunit, putative.
     
 0.820
PITG_16376
VWFA domain-containing protein.
    
 0.819
PITG_04613
DNA_ligase_A_N domain-containing protein.
   
 0.787
PITG_10592
DEAD/DEAH box RNA helicase, putative.
   
 
 0.753
PITG_15925
WLM domain-containing protein.
    
 
 0.746
PITG_16978
Crossover junction endonuclease MUS81-like protein.
   
 
 0.718
PITG_12229
DNA repair endonuclease XPF, putative.
   
 
 0.676
PITG_01902
PARP-type domain-containing protein.
   
  
 0.614
Your Current Organism:
Phytophthora infestans
NCBI taxonomy Id: 403677
Other names: P. infestans T30-4, Phytophthora infestans T30-4, Phytophthora infestans strain T30-4
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