node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Pmob_1083 | Pmob_1171 | Pmob_1083 | Pmob_1171 | PFAM: DNA mismatch repair protein MutS domain protein; KEGG: tme:Tmel_0195 DNA mismatch repair protein MutS domain protein. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.764 |
Pmob_1083 | Pmob_1482 | Pmob_1083 | Pmob_1482 | PFAM: DNA mismatch repair protein MutS domain protein; KEGG: tme:Tmel_0195 DNA mismatch repair protein MutS domain protein. | KEGG: tma:TM1395 hypothetical protein. | 0.764 |
Pmob_1083 | ligA | Pmob_1083 | Pmob_0996 | PFAM: DNA mismatch repair protein MutS domain protein; KEGG: tme:Tmel_0195 DNA mismatch repair protein MutS domain protein. | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | 0.436 |
Pmob_1083 | mutL | Pmob_1083 | Pmob_0599 | PFAM: DNA mismatch repair protein MutS domain protein; KEGG: tme:Tmel_0195 DNA mismatch repair protein MutS domain protein. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.976 |
Pmob_1083 | mutS | Pmob_1083 | Pmob_1004 | PFAM: DNA mismatch repair protein MutS domain protein; KEGG: tme:Tmel_0195 DNA mismatch repair protein MutS domain protein. | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.929 |
Pmob_1083 | mutS2 | Pmob_1083 | Pmob_0999 | PFAM: DNA mismatch repair protein MutS domain protein; KEGG: tme:Tmel_0195 DNA mismatch repair protein MutS domain protein. | Smr protein/MutS2; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. | 0.941 |
Pmob_1083 | polA | Pmob_1083 | Pmob_0077 | PFAM: DNA mismatch repair protein MutS domain protein; KEGG: tme:Tmel_0195 DNA mismatch repair protein MutS domain protein. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.851 |
Pmob_1083 | topA | Pmob_1083 | Pmob_1644 | PFAM: DNA mismatch repair protein MutS domain protein; KEGG: tme:Tmel_0195 DNA mismatch repair protein MutS domain protein. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.601 |
Pmob_1171 | Pmob_1083 | Pmob_1171 | Pmob_1083 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | PFAM: DNA mismatch repair protein MutS domain protein; KEGG: tme:Tmel_0195 DNA mismatch repair protein MutS domain protein. | 0.764 |
Pmob_1171 | mutL | Pmob_1171 | Pmob_0599 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.725 |
Pmob_1171 | mutS | Pmob_1171 | Pmob_1004 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.791 |
Pmob_1171 | polA | Pmob_1171 | Pmob_0077 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.992 |
Pmob_1171 | topA | Pmob_1171 | Pmob_1644 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.618 |
Pmob_1465 | mutL | Pmob_1465 | Pmob_0599 | PFAM: DNA repair protein RadC; KEGG: tma:TM1557 DNA repair protein; Belongs to the UPF0758 family. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.694 |
Pmob_1465 | mutS | Pmob_1465 | Pmob_1004 | PFAM: DNA repair protein RadC; KEGG: tma:TM1557 DNA repair protein; Belongs to the UPF0758 family. | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.639 |
Pmob_1465 | topA | Pmob_1465 | Pmob_1644 | PFAM: DNA repair protein RadC; KEGG: tma:TM1557 DNA repair protein; Belongs to the UPF0758 family. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.446 |
Pmob_1482 | Pmob_1083 | Pmob_1482 | Pmob_1083 | KEGG: tma:TM1395 hypothetical protein. | PFAM: DNA mismatch repair protein MutS domain protein; KEGG: tme:Tmel_0195 DNA mismatch repair protein MutS domain protein. | 0.764 |
Pmob_1482 | mutL | Pmob_1482 | Pmob_0599 | KEGG: tma:TM1395 hypothetical protein. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.706 |
Pmob_1482 | mutS | Pmob_1482 | Pmob_1004 | KEGG: tma:TM1395 hypothetical protein. | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.764 |
Pmob_1482 | polA | Pmob_1482 | Pmob_0077 | KEGG: tma:TM1395 hypothetical protein. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.990 |