Pmob_1291 protein (Petrotoga mobilis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

Pmob_1291

PFAM: regulatory protein MarR; KEGG: amt:Amet_0194 regulatory protein, MarR. (170 aa)

Predicted Functional Partners:

Pmob_0404

0.592

Pmob_1290

0.476

Pmob_0538

0.441

Pmob_1293

0.400

Your Current Organism:

Petrotoga mobilis

NCBI taxonomy Id: 403833
Other names: P. mobilis SJ95, Petrotoga mobilis DSM 10674, Petrotoga mobilis SJ95, Petrotoga mobilis str. SJ95, Petrotoga mobilis strain SJ95

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
Pmob_0404	Pmob_0538	PFAM: TPR repeat-containing protein; SMART: Tetratricopeptide domain protein; KEGG: cbf:CLI_1631 transcriptional regulator, LuxR family.	KEGG: mgm:Mmc1_2227 diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s); TIGRFAM: PAS sensor protein; diguanylate cyclase; PFAM: GGDEF domain containing protein; EAL domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein.	0.519
Pmob_0404	Pmob_1291	PFAM: TPR repeat-containing protein; SMART: Tetratricopeptide domain protein; KEGG: cbf:CLI_1631 transcriptional regulator, LuxR family.	PFAM: regulatory protein MarR; KEGG: amt:Amet_0194 regulatory protein, MarR.	0.592
Pmob_0538	Pmob_0404	KEGG: mgm:Mmc1_2227 diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s); TIGRFAM: PAS sensor protein; diguanylate cyclase; PFAM: GGDEF domain containing protein; EAL domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein.	PFAM: TPR repeat-containing protein; SMART: Tetratricopeptide domain protein; KEGG: cbf:CLI_1631 transcriptional regulator, LuxR family.	0.519
Pmob_0538	Pmob_1291	KEGG: mgm:Mmc1_2227 diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s); TIGRFAM: PAS sensor protein; diguanylate cyclase; PFAM: GGDEF domain containing protein; EAL domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein.	PFAM: regulatory protein MarR; KEGG: amt:Amet_0194 regulatory protein, MarR.	0.441
Pmob_1290	Pmob_1291	PFAM: transposase IS204/IS1001/IS1096/IS1165 family protein; KEGG: oih:OB2387 transposase for IS652.	PFAM: regulatory protein MarR; KEGG: amt:Amet_0194 regulatory protein, MarR.	0.476
Pmob_1291	Pmob_0404	PFAM: regulatory protein MarR; KEGG: amt:Amet_0194 regulatory protein, MarR.	PFAM: TPR repeat-containing protein; SMART: Tetratricopeptide domain protein; KEGG: cbf:CLI_1631 transcriptional regulator, LuxR family.	0.592
Pmob_1291	Pmob_0538	PFAM: regulatory protein MarR; KEGG: amt:Amet_0194 regulatory protein, MarR.	KEGG: mgm:Mmc1_2227 diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s); TIGRFAM: PAS sensor protein; diguanylate cyclase; PFAM: GGDEF domain containing protein; EAL domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein.	0.441
Pmob_1291	Pmob_1290	PFAM: regulatory protein MarR; KEGG: amt:Amet_0194 regulatory protein, MarR.	PFAM: transposase IS204/IS1001/IS1096/IS1165 family protein; KEGG: oih:OB2387 transposase for IS652.	0.476
Pmob_1291	Pmob_1293	PFAM: regulatory protein MarR; KEGG: amt:Amet_0194 regulatory protein, MarR.	PFAM: glycosyl transferase group 1; KEGG: cth:Cthe_2338 glycosyl transferase, group 1.	0.400
Pmob_1293	Pmob_1291	PFAM: glycosyl transferase group 1; KEGG: cth:Cthe_2338 glycosyl transferase, group 1.	PFAM: regulatory protein MarR; KEGG: amt:Amet_0194 regulatory protein, MarR.	0.400

Network Stats

number of nodes:

11

number of edges:

52

average node degree:

9.45

avg. local clustering coefficient:

0.939

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006817

Phosphate ion transport

11 of 12

2.58

10.85

4.25e-24

GO:0035435

Phosphate ion transmembrane transport

8 of 9

2.57

7.61

3.00e-16

GO:0055085

Transmembrane transport

10 of 368

1.05

1.33

1.49e-08

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005315

Inorganic phosphate transmembrane transporter activity

7 of 7

2.62

6.55

1.17e-13

GO:0042301

Phosphate ion binding

3 of 3

2.62

2.4

3.52e-05

GO:0015415

ATPase-coupled phosphate ion transmembrane transporter activity

3 of 3

2.62

2.4

3.52e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043190

ATP-binding cassette (ABC) transporter complex

3 of 54

1.36

0.79

0.0168

GO:0016021

Integral component of membrane

7 of 838

0.54

0.36

0.0192

GO:0005886

Plasma membrane

10 of 1476

0.45

0.33

0.0146

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:31133997

(2019) Identification of Resistance Genes and Response to Arsenic in Rhodococcus aetherivorans BCP1.

3 of 7

2.25

2.4

2.10e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6441

Phosphate ion transport

10 of 10

2.62

10.05

9.82e-22

CL:6438

Phosphate ion transport, and Polyphosphate kinase activity

11 of 18

2.4

9.59

8.08e-23

CL:6443

Inorganic phosphate transmembrane transporter activity

5 of 5

2.62

4.61

1.46e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

asd02010

ABC transporters

10 of 113

1.56

3.33

1.73e-13

asd02020

Two-component system

3 of 72

1.24

0.63

0.0370

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9637628

Modulation by Mtb of host immune system

3 of 12

2.02

1.96

0.00011

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005886

Plasma membrane

10 of 467

0.95

1.06

4.45e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0592

Phosphate transport

8 of 8

2.62

7.93

9.72e-17

KW-1278

Translocase

3 of 17

1.86

1.57

0.00062

KW-1003

Cell membrane

7 of 163

1.25

1.56

1.83e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00528

Binding-protein-dependent transport system inner membrane component

4 of 38

1.64

1.34

0.0012

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR024370

PBP domain

3 of 3

2.62

1.89

0.00033

IPR005670

Phosphate transport system permease protein 1

3 of 3

2.62

1.89

0.00033

IPR000515

ABC transporter type 1, transmembrane domain MetI-like

4 of 38

1.64

1.37

0.0010

IPR035906

MetI-like superfamily

4 of 39

1.63

1.36

0.0010

IPR011864

Phosphate ABC transporter, permease protein PstC

2 of 2

2.62

1.1

0.0100

(more ...)

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