STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ruvCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (163 aa)    
Predicted Functional Partners:
ruvA
Helix-hairpin-helix motif; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
 
 
 0.969
ruvB
Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
 
 
 0.939
Pmob_1482
KEGG: tma:TM1395 hypothetical protein.
     
 0.817
polC
DNA polymerase III, alpha subunit; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
     
 0.804
Pmob_1485
PFAM: peptidase M24; KEGG: cbf:CLI_0620 Xaa-Pro aminopeptidase.
  
    0.787
recX
Regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family.
  
  
 0.554
Pmob_0807
PFAM: protein of unknown function DUF28; KEGG: tpt:Tpet_0454 protein of unknown function DUF28.
 
  
 0.533
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
     
 0.518
Pmob_1487
PFAM: flagellar protein FliS; KEGG: tme:Tmel_0557 flagellar protein FliS.
   
   0.518
Pmob_1481
KEGG: tpt:Tpet_0265 serine O-acetyltransferase.
       0.490
Your Current Organism:
Petrotoga mobilis
NCBI taxonomy Id: 403833
Other names: P. mobilis SJ95, Petrotoga mobilis DSM 10674, Petrotoga mobilis SJ95, Petrotoga mobilis str. SJ95, Petrotoga mobilis strain SJ95
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