node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Pmob_0219 | apt | Pmob_0219 | Pmob_1065 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: tme:Tmel_1243 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.955 |
Pmob_0219 | fhs | Pmob_0219 | Pmob_1756 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: tme:Tmel_1243 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tme:Tmel_0304 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.509 |
Pmob_0219 | folD | Pmob_0219 | Pmob_1757 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: tme:Tmel_1243 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.840 |
Pmob_0219 | glyA | Pmob_0219 | Pmob_1468 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: tme:Tmel_1243 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.847 |
Pmob_0219 | guaB | Pmob_0219 | Pmob_1904 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: tme:Tmel_1243 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.862 |
Pmob_0219 | purA | Pmob_0219 | Pmob_1365 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: tme:Tmel_1243 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.994 |
Pmob_0219 | purD | Pmob_0219 | Pmob_1775 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: tme:Tmel_1243 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | KEGG: cpr:CPR_0676 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; protein of unknown function DUF201; Belongs to the GARS family. | 0.934 |
Pmob_0219 | purH | Pmob_0219 | Pmob_1777 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: tme:Tmel_1243 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | KEGG: ctc:CTC01962 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.983 |
Pmob_0219 | purM | Pmob_0219 | Pmob_1779 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: tme:Tmel_1243 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: sat:SYN_00889 phosphoribosylformylglycinamidine cyclo-ligase. | 0.879 |
Pmob_0219 | purN | Pmob_0219 | Pmob_1778 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: tme:Tmel_1243 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.884 |
apt | Pmob_0219 | Pmob_1065 | Pmob_0219 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: tme:Tmel_1243 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.955 |
apt | guaB | Pmob_1065 | Pmob_1904 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.497 |
apt | purA | Pmob_1065 | Pmob_1365 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.568 |
apt | purH | Pmob_1065 | Pmob_1777 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | KEGG: ctc:CTC01962 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.945 |
apt | purM | Pmob_1065 | Pmob_1779 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: sat:SYN_00889 phosphoribosylformylglycinamidine cyclo-ligase. | 0.470 |
apt | purN | Pmob_1065 | Pmob_1778 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.455 |
fhs | Pmob_0219 | Pmob_1756 | Pmob_0219 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tme:Tmel_0304 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: tme:Tmel_1243 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.509 |
fhs | folD | Pmob_1756 | Pmob_1757 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tme:Tmel_0304 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.997 |
fhs | glyA | Pmob_1756 | Pmob_1468 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tme:Tmel_0304 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.960 |
fhs | purD | Pmob_1756 | Pmob_1775 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tme:Tmel_0304 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | KEGG: cpr:CPR_0676 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; protein of unknown function DUF201; Belongs to the GARS family. | 0.629 |