node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Gbem_1297 | Gbem_3026 | Gbem_1297 | Gbem_3026 | HAD superfamily hydrolase. | Deoxycytidylate deaminase. | 0.918 |
Gbem_1297 | dut | Gbem_1297 | Gbem_1310 | HAD superfamily hydrolase. | Deoxyuridine-5'-triphosphate pyrophosphohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.902 |
Gbem_1297 | surE | Gbem_1297 | Gbem_2685 | HAD superfamily hydrolase. | Nucleoside 3'/5'-monophosphate phosphatase and short-chain exopolyphosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.914 |
Gbem_1297 | thyX | Gbem_1297 | Gbem_3711 | HAD superfamily hydrolase. | Thymidylate synthase, FAD-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.903 |
Gbem_1297 | tmk | Gbem_1297 | Gbem_3204 | HAD superfamily hydrolase. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.905 |
Gbem_2156 | dut | Gbem_2156 | Gbem_1310 | Deoxycytidine triphosphate deaminase/deoxyuridine triphosphate pyrophosphohydrolase. | Deoxyuridine-5'-triphosphate pyrophosphohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.929 |
Gbem_2156 | ndk | Gbem_2156 | Gbem_1654 | Deoxycytidine triphosphate deaminase/deoxyuridine triphosphate pyrophosphohydrolase. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.930 |
Gbem_3026 | Gbem_1297 | Gbem_3026 | Gbem_1297 | Deoxycytidylate deaminase. | HAD superfamily hydrolase. | 0.918 |
Gbem_3026 | dut | Gbem_3026 | Gbem_1310 | Deoxycytidylate deaminase. | Deoxyuridine-5'-triphosphate pyrophosphohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.950 |
Gbem_3026 | surE | Gbem_3026 | Gbem_2685 | Deoxycytidylate deaminase. | Nucleoside 3'/5'-monophosphate phosphatase and short-chain exopolyphosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
Gbem_3026 | thyX | Gbem_3026 | Gbem_3711 | Deoxycytidylate deaminase. | Thymidylate synthase, FAD-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.928 |
Gbem_3026 | tmk | Gbem_3026 | Gbem_3204 | Deoxycytidylate deaminase. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.932 |
coaBC | dut | Gbem_1667 | Gbem_1310 | Phosphopantothenylcysteine decarboxylase and phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Deoxyuridine-5'-triphosphate pyrophosphohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.938 |
dnaN | dut | Gbem_0002 | Gbem_1310 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Deoxyuridine-5'-triphosphate pyrophosphohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.874 |
dnaN | nrdJ | Gbem_0002 | Gbem_1201 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ribonucleoside diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.874 |
dut | Gbem_1297 | Gbem_1310 | Gbem_1297 | Deoxyuridine-5'-triphosphate pyrophosphohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | HAD superfamily hydrolase. | 0.902 |
dut | Gbem_2156 | Gbem_1310 | Gbem_2156 | Deoxyuridine-5'-triphosphate pyrophosphohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Deoxycytidine triphosphate deaminase/deoxyuridine triphosphate pyrophosphohydrolase. | 0.929 |
dut | Gbem_3026 | Gbem_1310 | Gbem_3026 | Deoxyuridine-5'-triphosphate pyrophosphohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Deoxycytidylate deaminase. | 0.950 |
dut | coaBC | Gbem_1310 | Gbem_1667 | Deoxyuridine-5'-triphosphate pyrophosphohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Phosphopantothenylcysteine decarboxylase and phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.938 |
dut | dnaN | Gbem_1310 | Gbem_0002 | Deoxyuridine-5'-triphosphate pyrophosphohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.874 |