node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDF76576.1 | hisA | SAMN05421827_101466 | SAMN05421827_10763 | D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.559 |
SDF76576.1 | hisC | SAMN05421827_101466 | SAMN05421827_10766 | D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.858 |
SDF76576.1 | hisD | SAMN05421827_101466 | SAMN05421827_10767 | D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.841 |
SDF76576.1 | hisF | SAMN05421827_101466 | SAMN05421827_10761 | D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase. | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.769 |
SDF76576.1 | hisG | SAMN05421827_101466 | SAMN05421827_10768 | D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.512 |
SDF76576.1 | hisH | SAMN05421827_101466 | SAMN05421827_10764 | D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase. | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.792 |
SDF76576.1 | hisI | SAMN05421827_101466 | SAMN05421827_10760 | D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase. | phosphoribosyl-ATP pyrophosphohydrolase / phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.945 |
SDH31763.1 | hisA | SAMN05421827_12125 | SAMN05421827_10763 | D-3-phosphoglycerate dehydrogenase. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.772 |
SDH31763.1 | hisB | SAMN05421827_12125 | SAMN05421827_10765 | D-3-phosphoglycerate dehydrogenase. | Imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.831 |
SDH31763.1 | hisC | SAMN05421827_12125 | SAMN05421827_10766 | D-3-phosphoglycerate dehydrogenase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.833 |
SDH31763.1 | hisD | SAMN05421827_12125 | SAMN05421827_10767 | D-3-phosphoglycerate dehydrogenase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.799 |
SDH31763.1 | hisF | SAMN05421827_12125 | SAMN05421827_10761 | D-3-phosphoglycerate dehydrogenase. | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.953 |
SDH31763.1 | hisG | SAMN05421827_12125 | SAMN05421827_10768 | D-3-phosphoglycerate dehydrogenase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.609 |
SDH31763.1 | hisH | SAMN05421827_12125 | SAMN05421827_10764 | D-3-phosphoglycerate dehydrogenase. | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.736 |
SDH31763.1 | hisI | SAMN05421827_12125 | SAMN05421827_10760 | D-3-phosphoglycerate dehydrogenase. | phosphoribosyl-ATP pyrophosphohydrolase / phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.994 |
SDH31763.1 | trpF | SAMN05421827_12125 | SAMN05421827_10116 | D-3-phosphoglycerate dehydrogenase. | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. | 0.952 |
hisA | SDF76576.1 | SAMN05421827_10763 | SAMN05421827_101466 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase. | 0.559 |
hisA | SDH31763.1 | SAMN05421827_10763 | SAMN05421827_12125 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | D-3-phosphoglycerate dehydrogenase. | 0.772 |
hisA | hisB | SAMN05421827_10763 | SAMN05421827_10765 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.999 |
hisA | hisC | SAMN05421827_10763 | SAMN05421827_10766 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.982 |