STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
OTA19379.1Type I restriction-modification system, M subunit. (859 aa)    
Predicted Functional Partners:
OTA19378.1
Type I restriction-modification.
 
 0.998
OTA19377.1
Type I restriction-modification system, R subunit; Subunit R is required for both nuclease and ATPase activities, but not for modification.
 
 
 0.993
OTA18873.1
Type I restriction endonuclease subunit S.
 
 
 0.992
OTA18871.1
DEAD/DEAH box helicase; Subunit R is required for both nuclease and ATPase activities, but not for modification.
 
 
 0.987
OTA19381.1
S-adenosylhomocysteine hydrolase.
       0.819
OTA19380.1
Pyrophosphatase.
       0.780
OTA18872.1
Anticodon nuclease.
 
   
 0.727
uvrB
Eukaryotic translation initiation factor 4A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA sub [...]
    
 
 0.624
OTA19382.1
3-phenylpropionic acid transporter.
       0.423
guaB
Inosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
   0.412
Your Current Organism:
Xenorhabdus beddingii
NCBI taxonomy Id: 40578
Other names: ATCC 49542, DSM 4764, UQM 2871, X. beddingii, Xenorhabdus nematophila subsp. beddingi, Xenorhabdus nematophilus subsp. beddingii, strain Q58, strain Q58/1
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.